Synthesis of protein-nucleic acid conjugates by expressed protein ligation

The synthesis of covalent conjugates of proteins and polyamide nucleic acids (PNA) is accomplished by expressed protein ligation of intein-fusion proteins and a PNA-cysteine conjugate.

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2003-04 (7), p.822-823
Main Authors: Lovrinovic, Marina, Seidel, Ralf, Wacker, Ron, Schroeder, Hendrik, Seitz, Oliver, Engelhard, Martin, Goody, Roger S, Niemeyer, Christof M
Format: Article
Language:English
Subjects:
Amino Acids - chemistry
Base Sequence
Cysteine - chemistry
DNA - chemistry
Escherichia coli - metabolism
Nucleic Acid Hybridization
Nucleic Acids - chemistry
Nucleic Acids - metabolism
Oligonucleotide Array Sequence Analysis
Peptide Nucleic Acids - chemical synthesis
Peptide Nucleic Acids - metabolism
Protein Splicing
Proteins - chemical synthesis
Proteins - genetics
Proteins - metabolism
Recombinant Fusion Proteins - genetics
Recombinant Fusion Proteins - metabolism
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Description
Summary:The synthesis of covalent conjugates of proteins and polyamide nucleic acids (PNA) is accomplished by expressed protein ligation of intein-fusion proteins and a PNA-cysteine conjugate.
ISSN:1359-7345
1364-548X
DOI:10.1039/b212294d