Bone marrow angiogenesis and its correlation with other disease characteristics in multiple myeloma in stage I versus stage II-III

We studied bone marrow angiogenesis in different stages of multiple myeloma according to the Durie and Salmon classification and its correlations with other disease characteristics. Sixty-five immunohistochemical CD34-stained, paraffin-embedded bone marrow biopsies of multiple myeloma patients and 1...

Full description

Saved in:
Bibliographic Details
Published in:Journal of cancer research and clinical oncology 2003-04, Vol.129 (4), p.234-238
Main Authors: NIEMÖLLER, Kathrin, JAKOB, Christian, HEIDER, Ulrike, ZAVRSKI, Ivana, EUCKER, Jan, KAUFMANN, Olaf, POSSINGER, Kurt, SEZER, Orhan
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Angiogenesis Inhibitors - therapeutic use
Biological and medical sciences
Bone marrow
Bone Marrow - blood supply
Disease
Female
Genes
Hematologic and hematopoietic diseases
Humans
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Male
Medical sciences
Middle Aged
Multiple Myeloma - drug therapy
Multiple Myeloma - pathology
Neoplasm Staging
Neovascularization, Pathologic - pathology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We studied bone marrow angiogenesis in different stages of multiple myeloma according to the Durie and Salmon classification and its correlations with other disease characteristics. Sixty-five immunohistochemical CD34-stained, paraffin-embedded bone marrow biopsies of multiple myeloma patients and 12 controls were studied. The mean number of microvessels per area in each sample was determined as the microvessel density (MVD). In addition, plasma cell infiltration of the bone marrow, serum beta2-microglobulin, immunoglobulin levels, C-reactive protein, and serum calcium concentration were measured in 22 patients with stage I multiple myeloma and in 43 patients in stage II-III. In myeloma patients, the bone marrow MVD was significantly higher than in controls (P
ISSN:0171-5216
1432-1335
DOI:10.1007/s00432-003-0432-z