Matrix metalloproteinase-12 is expressed in phagocytotic macrophages in active multiple sclerosis lesions

Matrix metalloproteinases (MMPs) are proteases involved in extracellular matrix (ECM) remodeling, leukocyte infiltration into lesions and myelin degradation in the central nervous system (CNS) disease multiple sclerosis (MS). We have investigated whether MMP-12 (macrophage metalloelastase) is expres...

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Bibliographic Details
Published in:Journal of neuroimmunology 2003-05, Vol.138 (1), p.106-114
Main Authors: Vos, Catharina M.P., van Haastert, Elise S., de Groot, Corline J.A., van der Valk, Paul, de Vries, Helga E.
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
alveolar macrophage elastase
Brain - enzymology
Brain - pathology
Central nervous system
Female
Humans
Immunohistochemistry
Macrophages - enzymology
Male
Matrix Metalloproteinase 12
Matrix metalloproteinases
Metalloendopeptidases - biosynthesis
Middle Aged
MMP-12 (macrophage metalloelastase)
Multiple sclerosis
Multiple Sclerosis - enzymology
Multiple Sclerosis - pathology
Multiple Sclerosis, Chronic Progressive - enzymology
Multiple Sclerosis, Chronic Progressive - pathology
Palatine Tonsil - cytology
Palatine Tonsil - enzymology
Phagocytosis
Placenta - cytology
Placenta - enzymology
Retrospective Studies
Spleen - cytology
Spleen - enzymology
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Summary:Matrix metalloproteinases (MMPs) are proteases involved in extracellular matrix (ECM) remodeling, leukocyte infiltration into lesions and myelin degradation in the central nervous system (CNS) disease multiple sclerosis (MS). We have investigated whether MMP-12 (macrophage metalloelastase) is expressed in MS lesions at various stages. In control patient tissue and (p)reactive MS lesions, only occasional microglial and astrocyte staining was detected. In contrast, in active demyelinating lesions, phagocytic macrophages were MMP-12 positive. A lower proportion of phagocytes was positive for MMP-12 in chronic active demyelinating lesions and inactive lesions. This suggests a role for MMP-12 during demyelination in MS.
ISSN:0165-5728
1872-8421
DOI:10.1016/S0165-5728(03)00036-5