A pilot neuropsychological study of Kraepelinian and non-Kraepelinian schizophrenia

Objective: This is the first study to report a direct comparison of neuropsychological performance in Kraepelinian vs. non-Kraepelinian schizophrenia (SZ). Methods: 17 Kraepelinian and 19 non-Kraepelinian subjects were assessed on a neuropsychological battery including the Purdue Pegboard, Schwartz&...

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Bibliographic Details
Published in:Schizophrenia research 2003-07, Vol.62 (1), p.155-163
Main Authors: Roy, Marc-André, Lehoux, Catherine, Émond, Claudia, Laplante, Louis, Bouchard, Roch-Hugo, Everett, James, Mérette, Chantal, Maziade, Michel
Format: Article
Language:English
Subjects:
Adult
Adult and adolescent clinical studies
Biological and medical sciences
Diagnosis, Differential
Diagnostic and Statistical Manual of Mental Disorders
Female
Follow-Up Studies
Genetics
Humans
Kraepelinian
Male
Mathematical Computing
Medical sciences
Middle Aged
Neuropsychological Tests - statistics & numerical data
Neuropsychology
Nosology. Terminology. Diagnostic criteria
Outcome
Patient Admission
Psychology. Psychoanalysis. Psychiatry
Psychometrics - statistics & numerical data
Psychopathology. Psychiatry
Psychoses
Reference Values
Schizophrenia
Schizophrenia - classification
Schizophrenia - diagnosis
Schizophrenia - genetics
Schizophrenia - therapy
Schizophrenic Psychology
Subtypes
Techniques and methods
Treatment Outcome
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Summary:Objective: This is the first study to report a direct comparison of neuropsychological performance in Kraepelinian vs. non-Kraepelinian schizophrenia (SZ). Methods: 17 Kraepelinian and 19 non-Kraepelinian subjects were assessed on a neuropsychological battery including the Purdue Pegboard, Schwartz' Reaction Time task, the Modified Card Sorting Test, the Wechsler's Associate Learning Test and the Digit Span. Results: Kraepelinian schizophrenia was characterized by more impaired performance on the Purdue Pegboard and the Card Sorting test. These differences remained significant when introducing, as covariates, the type of neuroleptic used, the use of anticholinergic medication, age and gender. Differences on the Reaction Time, the Associate Learning and the Digit Span tasks did not reach statistical significance. Conclusions: These results suggest that Kraepelinian schizophrenia is characterized by impaired performance on fine motor dexterity and executive functioning. These results further add to the evidence for the validity of the distinction between Kraepelinian and non-Kraepelinian schizophrenia as a strategy to better understand the factors influencing severity and/or outcome in schizophrenia.
ISSN:0920-9964
1573-2509
DOI:10.1016/S0920-9964(02)00481-4