Clonal rearrangement of chromosome band 6p21 in the mesenchymal component of pulmonary chondroid hamartoma

Pulmonary chondroid hamartomas (PCH) are biphasic benign tumors that contain both mesenchymal and epithelial populations. In this report we describe two PCH in which clonal translocations at chromosome band 6p21 were demonstrated in mesenchymal cells. One of these had a unique translocation, t(6;14)...

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Bibliographic Details
Published in:Cancer research (Chicago, Ill.) Ill.), 1992-11, Vol.52 (22), p.6224-6228
Main Authors: FLETCHER, J. A, PINKUS, G. S, DONOVAN, K, NAEEM, R, SUGARBAKER, D. J, MENTZER, S, PINKUS, J. L, LONGTINE, J
Format: Article
Language:English
Subjects:
Adult
Aged
Biological and medical sciences
Chromosome Aberrations - physiology
Chromosomes, Human, Pair 11 - physiology
Chromosomes, Human, Pair 12 - physiology
Chromosomes, Human, Pair 14 - physiology
Chromosomes, Human, Pair 18 - physiology
Chromosomes, Human, Pair 6 - physiology
Female
Gene Rearrangement - genetics
Hamartoma - genetics
Humans
Immunohistochemistry
Karyotyping
Lung Neoplasms - genetics
Male
Medical sciences
Mesoderm - pathology
Mesoderm - physiology
Pneumology
Translocation, Genetic - genetics
Tumors of the respiratory system and mediastinum
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Summary:Pulmonary chondroid hamartomas (PCH) are biphasic benign tumors that contain both mesenchymal and epithelial populations. In this report we describe two PCH in which clonal translocations at chromosome band 6p21 were demonstrated in mesenchymal cells. One of these had a unique translocation, t(6;14)(p21;q24), that was also found in one of two PCH karyotyped previously. The t(6;14) has not been described in other varieties of benign or malignant neoplasia. The 6p21 aberrations are of particular interest because break points in this chromosomal region appear to be characteristic of endometrial polyps. Endometrial polyps, like PCH, are biphasic benign tumors in which mesenchymal clonality has been demonstrated.
ISSN:0008-5472
1538-7445