Characterization of wheezing phenotypes in the first 10 years of life

Summary Background Childhood wheezing illnesses are characterized into different phenotypes. However, severity of the disease associated with these phenotypes has not been extensively studied. Objectives To determine characteristics of childhood wheezing phenotypes in the first decade of life using...

Full description

Saved in:
Bibliographic Details
Published in:Clinical and experimental allergy 2003-05, Vol.33 (5), p.573-578
Main Authors: Kurukulaaratchy, R. J., Fenn, M. H., Waterhouse, L. M., Matthews, S. M., Holgate, S. T., Arshad, S. H.
Format: Article
Language:English
Subjects:
Age of Onset
Allergic diseases
atopy
Biological and medical sciences
bronchial hyper-responsiveness
Bronchial Hyperreactivity - blood
Bronchial Hyperreactivity - epidemiology
Bronchial Hyperreactivity - genetics
childhood asthma
England - epidemiology
Female
Follow-Up Studies
Glucocorticoids - administration & dosage
Health Resources - statistics & numerical data
Hospitalization - statistics & numerical data
Humans
Hypersensitivity - epidemiology
Immunopathology
Infant, Newborn
Male
Medical sciences
Morbidity
Phenotype
Prognosis
Prospective Studies
Referral and Consultation - statistics & numerical data
Respiratory and ent allergic diseases
Respiratory Mechanics
Respiratory Sounds - diagnosis
Respiratory Sounds - physiopathology
wheezing phenotypes
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Summary Background Childhood wheezing illnesses are characterized into different phenotypes. However, severity of the disease associated with these phenotypes has not been extensively studied. Objectives To determine characteristics of childhood wheezing phenotypes in the first decade of life using health outcomes plus measurements of atopy, lung function and bronchial hyper‐responsiveness. Methods A whole population birth cohort (n = 1456) was prospectively studied to examine the natural history of childhood wheezing. Children were seen at 1, 2, 4 and 10 years for questionnaire completion and prospectively collected data used to define wheezing phenotypes. Assessment was made of adverse health outcomes plus spirometry, bronchial hyper‐responsiveness, serum IgE measurement at 10 years and skin test sensitization at both 4 and 10 years for wheezing phenotypes. Results Phenotypic analysis identified that 37% early life wheezers (symptom onset by age 4 years) still wheezed at 10 years. These persistent wheezers showed significantly more physician‐diagnosed asthma in early life (P 
ISSN:0954-7894
1365-2222
DOI:10.1046/j.1365-2222.2003.01657.x