Compensatory subendocardial hyperkinesis in the cat is abolished during coronary insufficiency outside an acutely ischaemic region

Objective: The aims were to determine (1) whether acute coronary occlusion provoked uniform hyperkinesis in remote non-ischaemic myocardium, and (2) how subsequent coronary stenosis affected such hyperkinesis. Methods: Two pairs of ultrasonic crystals were placed in the anterior left ventricular mid...

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Bibliographic Details
Published in:Cardiovascular research 1992-03, Vol.26 (3), p.285-291
Main Authors: Birkeland, Sigurd, Westby, Joergen, Hessevik, Idar, Grong, Ketil, Hexeberg, Erik, Lekven, Jon
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Blood Pressure - physiology
Cardiology. Vascular system
Cats
Coronary Disease - physiopathology
Coronary heart disease
coronary stenosis
Disease Models, Animal
Heart
Heart - physiopathology
Male
Medical sciences
myocardial blood flow
myocardial contraction
Myocardial Infarction - physiopathology
myocardial ischaemia
Perfusion
Regional Blood Flow - physiology
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Summary:Objective: The aims were to determine (1) whether acute coronary occlusion provoked uniform hyperkinesis in remote non-ischaemic myocardium, and (2) how subsequent coronary stenosis affected such hyperkinesis. Methods: Two pairs of ultrasonic crystals were placed in the anterior left ventricular midwall of nine pentobarbitone anaesthetised open chest cats. One pair (longitudinal) ran parallel to subendocardial fibres; the other pair (circumferential) was aligned with subepicardial and mid-myocardial fibres. Following circumflex coronary occlusion, subsequent hypoperfusion of the anterior wall was established by controlled constriction of a shunt line from the right subclavian artery to the left main coronary artery in two discrete steps. Results: Following circumflex occlusion maximum systolic shortening of segments aligned to subendocardial fibres increased from 6.7(SEM 0.9)% to 11.5(1.4)% (p
ISSN:0008-6363
1755-3245
DOI:10.1093/cvr/26.3.285