The chiral chromatographic separation of β-adrenoceptor blocking drugs

Over 100 chromatographic procedures for the separation of β-blocker enantiomers are reviewed including a large number for the analysis of biological samples. All the principal chiral chromatographic procedures have found use, namely Chiral Mobile Phase Additives (CMPA), Chiral Derivatization Agents...

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Bibliographic Details
Published in:Journal of pharmaceutical and biomedical analysis 1992-06, Vol.10 (6), p.383-404
Main Author: Dyas, A.M.
Format: Article
Language:English
Subjects:
Adrenergic beta-Antagonists - analysis
Analysis
Biological and medical sciences
chiral separation
chromatographic separation
Chromatography, Gas
Chromatography, Thin Layer
enantiomers
General pharmacology
Medical sciences
optical isomers
Pharmacology. Drug treatments
Review
Stereoisomerism
β-blockers
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Summary:Over 100 chromatographic procedures for the separation of β-blocker enantiomers are reviewed including a large number for the analysis of biological samples. All the principal chiral chromatographic procedures have found use, namely Chiral Mobile Phase Additives (CMPA), Chiral Derivatization Agents (CDA) and Chiral Stationary Phases (CSP). Chiral Mobile Phase Additives are less frequently employed than the other two procedures and many of the earlier methods were based on the use of CDAs. However, the recent development of sophisticated custom-made CSPs has allowed the separation of native (underivatized) analytes and this approach appears to be gaining in popularity. The β-blockers are an extensive group of drugs and stereoselective separations have been reported for 40 different structures.
ISSN:0731-7085
1873-264X
DOI:10.1016/0731-7085(92)80057-T