Nitric Oxide Synthase in Cardiac Nerve Fibers and Neurons of Rat and Guinea Pig Heart

Participation of nitric oxide (NO) in the autonomic innervation of rat and guinea pig hearts was investigated by applying the NADPH diaphorase technique and immunohistochemistry with NO synthase antiserum. We present evidence that NO synthase is localized in cardiac ganglion cells and nerve fibers i...

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Bibliographic Details
Published in:Circulation research 1992-12, Vol.71 (6), p.1533-1537
Main Authors: Klimaschewski, Lars, Kummer, Wolfgang, Mayer, Bernd, Couraud, Jean Yves, Preissler, Ulrike, Philippin, Bärbel, Heym, Christine
Format: Article
Language:English
Subjects:
Amino Acid Oxidoreductases - analysis
Animals
Biological and medical sciences
Coronary Vessels - physiology
Fundamental and applied biological sciences. Psychology
Guinea Pigs
Heart
Heart - innervation
Heart - physiology
Heart Rate
Histocytochemistry
Myocardium - enzymology
NADPH Dehydrogenase
Nerve Fibers - enzymology
Neurons - enzymology
Nitric Oxide - metabolism
Nitric Oxide Synthase
Rats
Vasodilation
Vertebrates: cardiovascular system
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Summary:Participation of nitric oxide (NO) in the autonomic innervation of rat and guinea pig hearts was investigated by applying the NADPH diaphorase technique and immunohistochemistry with NO synthase antiserum. We present evidence that NO synthase is localized in cardiac ganglion cells and nerve fibers innervating the sinuatrial and atrioventricular nodes, the myocardium, local neurons, coronary arteries, and pulmonary vessels, suggesting an involvement of NO in neurogenic heart rate regulation, myocardial cell function, neuronal transmission in cardiac ganglia, and coronary as well as pulmonary vasodilation.
ISSN:0009-7330
1524-4571
DOI:10.1161/01.res.71.6.1533