Familial Resemblance of Blood Pressure with Residual Household Environmental Effects in Consanguineous and Nonconsanguineous Families from Andhra Pradesh, India

Familial aggregation of blood pressure (BP), both systolic (SBP) and diastolic (DBP), was examined in consanguineous and nonconsanguineous families from southern India. Path analysis of BP suggests inbreeding effects, with the genetic variance for SBP being lower in the sample that included inbred f...

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Bibliographic Details
Published in:Human biology 1992-12, Vol.64 (6), p.869-889
Main Authors: RICE, TREVA, NIRMALA, A., REDDY, P. CHENGAL, RAMANA, P. VENKATA, KRISHNA, K. SREERAMA, RAO, D.C.
Format: Article
Language:English
Subjects:
Anthropology. Demography
Biological and medical sciences
Blood pressure
Blood Pressure - genetics
Consanguinity
Coronary heart disease
Developing Countries
Disease
Familial diseases
Families & family life
Female
Genetic aspects
Genetics
Genetics, Population
Heritability
Human genetics
Human physiology applied to population studies and life conditions. Human ecophysiology
Humans
Hypertension - genetics
Inbreeding
India
Life Style
Male
Medical genetics
Medical research
Medical sciences
Models, Genetic
Parametric models
Phenotype
Phenotypes
Reproduction
Risk factors
Siblings
Social Environment
Spouses
Statistical variance
Tropical medicine
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Summary:Familial aggregation of blood pressure (BP), both systolic (SBP) and diastolic (DBP), was examined in consanguineous and nonconsanguineous families from southern India. Path analysis of BP suggests inbreeding effects, with the genetic variance for SBP being lower in the sample that included inbred families. Specifically, genetic heritability for SBP was 38% in the nonconsanguineous sample but only 23% in the combined sample. Genetic heritability for DBP (30%) did not vary by sample, nor were sample differences in cultural heritability detected for either SBP (over 35%) or DBP (about 18%). These findings are remarkably similar to those in a French-Canadian population of Quebec; both reports found a considerably larger effect of the home environment on BP than previous studies.
ISSN:0018-7143
1534-6617