Blood Pressure Response to Hyperinsulinemia in Salt-Sensitive and Salt-Resistant Rats

We investigated the role of insulin in salt-sensitive hypertension in Dahl salt-sensitive and salt-resistant rats. The rats were kept in metabolic cages, and sodium intake and urinary sodium excretion were measured. In salt-sensitive rats receiving a 03% NaCl diet, sodium retention was significantly...

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Bibliographic Details
Published in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 1992-11, Vol.20 (5), p.596-600
Main Authors: Tomiyama, Hirofumi, Kushiro, Toshio, Abeta, Hiromi, Kurumatani, Hitoshi, Taguchi, Hisao, Kuga, Nobuyuki, Saito, Fumio, Kobayashi, Fumiyuki, Otsuka, Yuji, Kanmatsuse, Katsuo, Kajiwara, Nagao
Format: Article
Language:English
Subjects:
Animals
Arterial hypertension. Arterial hypotension
Biological and medical sciences
Blood and lymphatic vessels
Blood Pressure
Cardiology. Vascular system
Drug Resistance - genetics
Experimental diseases
Hyperinsulinism - blood
Hyperinsulinism - physiopathology
Hyperinsulinism - urine
Insulin - blood
Male
Medical sciences
Natriuresis
Norepinephrine - blood
Rats
Rats, Inbred Strains
Sodium Chloride - pharmacology
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Summary:We investigated the role of insulin in salt-sensitive hypertension in Dahl salt-sensitive and salt-resistant rats. The rats were kept in metabolic cages, and sodium intake and urinary sodium excretion were measured. In salt-sensitive rats receiving a 03% NaCl diet, sodium retention was significantly greater at weeks 1 and 2 in rats that received an insulin infusion than in those receiving a saline infusion. Mean arterial blood pressure and plasma norepinephrine levels were significantly higher at week 3 in insulin-treated rats than in saline-treated rats (mean arterial pressure, 137±3 mm Hg versus 119±3 mm Hg, p
ISSN:0194-911X
1524-4563
DOI:10.1161/01.hyp.20.5.596