Derivatization in Mass Spectrometry—1. Silylation

This is the first of a series of reviews on the application of derivatization in mass spectrometry. A description is given of advances in silylation as a powerful tool used for increasing the volatility, thermal and thermo-catalytic stability, and chromatographic mobility of polar and unstable organ...

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Bibliographic Details
Published in:European Journal of Mass Spectrometry 2003-01, Vol.9 (1), p.1-21
Main Authors: Halket, John M., Zaikin, Vladimir G.
Format: Article
Language:English
Subjects:
Mass Spectrometry - methods
Organosilicon Compounds - chemistry
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Summary:This is the first of a series of reviews on the application of derivatization in mass spectrometry. A description is given of advances in silylation as a powerful tool used for increasing the volatility, thermal and thermo-catalytic stability, and chromatographic mobility of polar and unstable organic compounds. In addition to chemical aspects of silylation, mass spectral properties of silyl derivatives useful for structure determination and quantitation of various organic and biologically-active compounds, mainly by GC/MS, are described. Practically all tested and widely used silylating agents are described. The role of comprehensive libraries containing reference mass spectra for various silyl derivatives and search systems in structure determination is emphasized. Applications of silylation for particular analyses are summarised.
ISSN:1469-0667
1751-6838
DOI:10.1255/ejms.527