Serial MRI in a case of familial hemiplegic migraine

We report MRI findings in a patient with familial hemiplegic migraine (FHM) with repeated episodes of hemiparesis. FHM is caused by a penetrant autosomal dominant genetic mutation; several mutations have been genotyped, involving brain-expressed ion channels. We found cerebral oedema, dilatation of...

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Bibliographic Details
Published in:Neuroradiology 2003-05, Vol.45 (5), p.300-303
Main Authors: BUTTERISS, D. J. A, RAMESH, V, BIRCHALL, D
Format: Article
Language:English
Subjects:
Adolescent
Biological and medical sciences
Brain - pathology
Hemiplegia - genetics
Hemiplegia - pathology
Humans
Magnetic Resonance Imaging
Male
Medical sciences
Migraine Disorders - genetics
Migraine Disorders - pathology
Mutation
Neurology
Vascular diseases and vascular malformations of the nervous system
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Summary:We report MRI findings in a patient with familial hemiplegic migraine (FHM) with repeated episodes of hemiparesis. FHM is caused by a penetrant autosomal dominant genetic mutation; several mutations have been genotyped, involving brain-expressed ion channels. We found cerebral oedema, dilatation of intracerebral vessels and decreased water diffusion contralateral to the hemiparesis, not respecting vascular territories, with subsequent complete resolution of both clinical and imaging abnormalities. These results are thought to be consistent with an underlying primary neuronal pathology with secondary vascular effects, as opposed to the traditional, primarily vascular, model of migraine aetiology.
ISSN:0028-3940
1432-1920
DOI:10.1007/s00234-003-0979-z