Clinical application of direct sputum sensitivity testing in a severe infective exacerbation of cystic fibrosis

A 16‐year‐old male with cystic fibrosis (CF) was admitted to hospital with a severe infective exacerbation. Despite standard management, including conventionally selected intravenous antibiotics for Pseudomonas aeruginosa, chest physiotherapy, and institution of noninvasive ventilation (NIV) for pro...

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Bibliographic Details
Published in:Pediatric pulmonology 2003-06, Vol.35 (6), p.463-466
Main Authors: Serisier, David J., Jones, Graeme, Tuck, Andrew, Connett, Gary, Carroll, Mary P.
Format: Article
Language:English
Subjects:
Adolescent
Antibacterial agents
antibiotic sensitivity
Antibiotics. Antiinfectious agents. Antiparasitic agents
Biological and medical sciences
cystic fibrosis
Cystic Fibrosis - complications
Cystic Fibrosis - drug therapy
Cystic Fibrosis - microbiology
Drug Resistance, Microbial
Humans
Male
Medical sciences
Microbial Sensitivity Tests - methods
microbiology
Pharmacology. Drug treatments
Pseudomonas aeruginosa
Pseudomonas aeruginosa - drug effects
Pseudomonas Infections - drug therapy
Respiratory Therapy
sputum
Sputum - microbiology
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Summary:A 16‐year‐old male with cystic fibrosis (CF) was admitted to hospital with a severe infective exacerbation. Despite standard management, including conventionally selected intravenous antibiotics for Pseudomonas aeruginosa, chest physiotherapy, and institution of noninvasive ventilation (NIV) for progressive hypercapneic respiratory failure, he continued to deteriorate. Direct sputum sensitivity testing (DSST) revealed a novel combination of antibiotics that resulted in a rapid and remarkable clinical improvement. DSST is a form of “whole” sputum sensitivity testing that provides information on antibiotic synergy, and may more accurately reflect in vivo antibiotic sensitivity patterns in cystic fibrosis. Pediatr Pulmonol. 2003; 35:463–466. © 2003 Wiley‐Liss, Inc.
ISSN:8755-6863
1099-0496
DOI:10.1002/ppul.10294