Loading…
Clinical application of direct sputum sensitivity testing in a severe infective exacerbation of cystic fibrosis
A 16‐year‐old male with cystic fibrosis (CF) was admitted to hospital with a severe infective exacerbation. Despite standard management, including conventionally selected intravenous antibiotics for Pseudomonas aeruginosa, chest physiotherapy, and institution of noninvasive ventilation (NIV) for pro...
Saved in:
| Published in: | Pediatric pulmonology 2003-06, Vol.35 (6), p.463-466 |
|---|---|
| Main Authors: | , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c3934-6c9e937f49f873433a5a4324dc0e30952e37c10fdbbc13bf5397bf29990b17ce3 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c3934-6c9e937f49f873433a5a4324dc0e30952e37c10fdbbc13bf5397bf29990b17ce3 |
| container_end_page | 466 |
| container_issue | 6 |
| container_start_page | 463 |
| container_title | Pediatric pulmonology |
| container_volume | 35 |
| creator | Serisier, David J. Jones, Graeme Tuck, Andrew Connett, Gary Carroll, Mary P. |
| description | A 16‐year‐old male with cystic fibrosis (CF) was admitted to hospital with a severe infective exacerbation. Despite standard management, including conventionally selected intravenous antibiotics for Pseudomonas aeruginosa, chest physiotherapy, and institution of noninvasive ventilation (NIV) for progressive hypercapneic respiratory failure, he continued to deteriorate. Direct sputum sensitivity testing (DSST) revealed a novel combination of antibiotics that resulted in a rapid and remarkable clinical improvement. DSST is a form of “whole” sputum sensitivity testing that provides information on antibiotic synergy, and may more accurately reflect in vivo antibiotic sensitivity patterns in cystic fibrosis. Pediatr Pulmonol. 2003; 35:463–466. © 2003 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/ppul.10294 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_73302205</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>73302205</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3934-6c9e937f49f873433a5a4324dc0e30952e37c10fdbbc13bf5397bf29990b17ce3</originalsourceid><addsrcrecordid>eNp9kEFv1DAQhS1ERbeFCz8A-QKHSil27MTrI1rRAtrCHlo4Wo53jAaySWon2-6_Z8ou7Y2TnzTfvDd-jL2W4lwKUb4fhqklVVr9jM2ksLYQ2tbP2Wxuqqqo57U6Zic5_xKCZla-YMeyNLq2Ws9Yv2ixw-Bb7oehJTFi3_E-8jUmCCPPwzROG56hyzjiFscdHyGP2P3k2HFPgy0kIB2Jxi1wuPcBUvPoE3ZEBx6xSX3G_JIdRd9meHV4T9nNxcfrxadi-e3y8-LDsgjKKl3UwYJVJmob50ZppXzltSr1OghQwlYlKBOkiOumCVI1sVLWNLGk74lGmgDqlL3b-w6pv53oYrfBHKBtfQf9lJ1RSpSlqAg824OB7ssJohsSbnzaOSncQ73uoV73t16C3xxcp2YD6yf00CcBbw-Az1RqTL4LmJ84PafU2hAn99wdtrD7T6RbrW6W_8KL_Q7mEe4fd3z67cjRVO7H10v35Xp1ZdXiu7tSfwBLXKPG</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>73302205</pqid></control><display><type>article</type><title>Clinical application of direct sputum sensitivity testing in a severe infective exacerbation of cystic fibrosis</title><source>Wiley-Blackwell Read & Publish Collection</source><creator>Serisier, David J. ; Jones, Graeme ; Tuck, Andrew ; Connett, Gary ; Carroll, Mary P.</creator><creatorcontrib>Serisier, David J. ; Jones, Graeme ; Tuck, Andrew ; Connett, Gary ; Carroll, Mary P.</creatorcontrib><description>A 16‐year‐old male with cystic fibrosis (CF) was admitted to hospital with a severe infective exacerbation. Despite standard management, including conventionally selected intravenous antibiotics for Pseudomonas aeruginosa, chest physiotherapy, and institution of noninvasive ventilation (NIV) for progressive hypercapneic respiratory failure, he continued to deteriorate. Direct sputum sensitivity testing (DSST) revealed a novel combination of antibiotics that resulted in a rapid and remarkable clinical improvement. DSST is a form of “whole” sputum sensitivity testing that provides information on antibiotic synergy, and may more accurately reflect in vivo antibiotic sensitivity patterns in cystic fibrosis. Pediatr Pulmonol. 2003; 35:463–466. © 2003 Wiley‐Liss, Inc.</description><identifier>ISSN: 8755-6863</identifier><identifier>EISSN: 1099-0496</identifier><identifier>DOI: 10.1002/ppul.10294</identifier><identifier>PMID: 12746944</identifier><identifier>CODEN: PEPUES</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adolescent ; Antibacterial agents ; antibiotic sensitivity ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Biological and medical sciences ; cystic fibrosis ; Cystic Fibrosis - complications ; Cystic Fibrosis - drug therapy ; Cystic Fibrosis - microbiology ; Drug Resistance, Microbial ; Humans ; Male ; Medical sciences ; Microbial Sensitivity Tests - methods ; microbiology ; Pharmacology. Drug treatments ; Pseudomonas aeruginosa ; Pseudomonas aeruginosa - drug effects ; Pseudomonas Infections - drug therapy ; Respiratory Therapy ; sputum ; Sputum - microbiology</subject><ispartof>Pediatric pulmonology, 2003-06, Vol.35 (6), p.463-466</ispartof><rights>Copyright © 2003 Wiley‐Liss, Inc.</rights><rights>2003 INIST-CNRS</rights><rights>Copyright 2003 Wiley-Liss, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3934-6c9e937f49f873433a5a4324dc0e30952e37c10fdbbc13bf5397bf29990b17ce3</citedby><cites>FETCH-LOGICAL-c3934-6c9e937f49f873433a5a4324dc0e30952e37c10fdbbc13bf5397bf29990b17ce3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14802267$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12746944$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Serisier, David J.</creatorcontrib><creatorcontrib>Jones, Graeme</creatorcontrib><creatorcontrib>Tuck, Andrew</creatorcontrib><creatorcontrib>Connett, Gary</creatorcontrib><creatorcontrib>Carroll, Mary P.</creatorcontrib><title>Clinical application of direct sputum sensitivity testing in a severe infective exacerbation of cystic fibrosis</title><title>Pediatric pulmonology</title><addtitle>Pediatr. Pulmonol</addtitle><description>A 16‐year‐old male with cystic fibrosis (CF) was admitted to hospital with a severe infective exacerbation. Despite standard management, including conventionally selected intravenous antibiotics for Pseudomonas aeruginosa, chest physiotherapy, and institution of noninvasive ventilation (NIV) for progressive hypercapneic respiratory failure, he continued to deteriorate. Direct sputum sensitivity testing (DSST) revealed a novel combination of antibiotics that resulted in a rapid and remarkable clinical improvement. DSST is a form of “whole” sputum sensitivity testing that provides information on antibiotic synergy, and may more accurately reflect in vivo antibiotic sensitivity patterns in cystic fibrosis. Pediatr Pulmonol. 2003; 35:463–466. © 2003 Wiley‐Liss, Inc.</description><subject>Adolescent</subject><subject>Antibacterial agents</subject><subject>antibiotic sensitivity</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Biological and medical sciences</subject><subject>cystic fibrosis</subject><subject>Cystic Fibrosis - complications</subject><subject>Cystic Fibrosis - drug therapy</subject><subject>Cystic Fibrosis - microbiology</subject><subject>Drug Resistance, Microbial</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microbial Sensitivity Tests - methods</subject><subject>microbiology</subject><subject>Pharmacology. Drug treatments</subject><subject>Pseudomonas aeruginosa</subject><subject>Pseudomonas aeruginosa - drug effects</subject><subject>Pseudomonas Infections - drug therapy</subject><subject>Respiratory Therapy</subject><subject>sputum</subject><subject>Sputum - microbiology</subject><issn>8755-6863</issn><issn>1099-0496</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><recordid>eNp9kEFv1DAQhS1ERbeFCz8A-QKHSil27MTrI1rRAtrCHlo4Wo53jAaySWon2-6_Z8ou7Y2TnzTfvDd-jL2W4lwKUb4fhqklVVr9jM2ksLYQ2tbP2Wxuqqqo57U6Zic5_xKCZla-YMeyNLq2Ws9Yv2ixw-Bb7oehJTFi3_E-8jUmCCPPwzROG56hyzjiFscdHyGP2P3k2HFPgy0kIB2Jxi1wuPcBUvPoE3ZEBx6xSX3G_JIdRd9meHV4T9nNxcfrxadi-e3y8-LDsgjKKl3UwYJVJmob50ZppXzltSr1OghQwlYlKBOkiOumCVI1sVLWNLGk74lGmgDqlL3b-w6pv53oYrfBHKBtfQf9lJ1RSpSlqAg824OB7ssJohsSbnzaOSncQ73uoV73t16C3xxcp2YD6yf00CcBbw-Az1RqTL4LmJ84PafU2hAn99wdtrD7T6RbrW6W_8KL_Q7mEe4fd3z67cjRVO7H10v35Xp1ZdXiu7tSfwBLXKPG</recordid><startdate>200306</startdate><enddate>200306</enddate><creator>Serisier, David J.</creator><creator>Jones, Graeme</creator><creator>Tuck, Andrew</creator><creator>Connett, Gary</creator><creator>Carroll, Mary P.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200306</creationdate><title>Clinical application of direct sputum sensitivity testing in a severe infective exacerbation of cystic fibrosis</title><author>Serisier, David J. ; Jones, Graeme ; Tuck, Andrew ; Connett, Gary ; Carroll, Mary P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3934-6c9e937f49f873433a5a4324dc0e30952e37c10fdbbc13bf5397bf29990b17ce3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adolescent</topic><topic>Antibacterial agents</topic><topic>antibiotic sensitivity</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Biological and medical sciences</topic><topic>cystic fibrosis</topic><topic>Cystic Fibrosis - complications</topic><topic>Cystic Fibrosis - drug therapy</topic><topic>Cystic Fibrosis - microbiology</topic><topic>Drug Resistance, Microbial</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microbial Sensitivity Tests - methods</topic><topic>microbiology</topic><topic>Pharmacology. Drug treatments</topic><topic>Pseudomonas aeruginosa</topic><topic>Pseudomonas aeruginosa - drug effects</topic><topic>Pseudomonas Infections - drug therapy</topic><topic>Respiratory Therapy</topic><topic>sputum</topic><topic>Sputum - microbiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Serisier, David J.</creatorcontrib><creatorcontrib>Jones, Graeme</creatorcontrib><creatorcontrib>Tuck, Andrew</creatorcontrib><creatorcontrib>Connett, Gary</creatorcontrib><creatorcontrib>Carroll, Mary P.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric pulmonology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Serisier, David J.</au><au>Jones, Graeme</au><au>Tuck, Andrew</au><au>Connett, Gary</au><au>Carroll, Mary P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical application of direct sputum sensitivity testing in a severe infective exacerbation of cystic fibrosis</atitle><jtitle>Pediatric pulmonology</jtitle><addtitle>Pediatr. Pulmonol</addtitle><date>2003-06</date><risdate>2003</risdate><volume>35</volume><issue>6</issue><spage>463</spage><epage>466</epage><pages>463-466</pages><issn>8755-6863</issn><eissn>1099-0496</eissn><coden>PEPUES</coden><abstract>A 16‐year‐old male with cystic fibrosis (CF) was admitted to hospital with a severe infective exacerbation. Despite standard management, including conventionally selected intravenous antibiotics for Pseudomonas aeruginosa, chest physiotherapy, and institution of noninvasive ventilation (NIV) for progressive hypercapneic respiratory failure, he continued to deteriorate. Direct sputum sensitivity testing (DSST) revealed a novel combination of antibiotics that resulted in a rapid and remarkable clinical improvement. DSST is a form of “whole” sputum sensitivity testing that provides information on antibiotic synergy, and may more accurately reflect in vivo antibiotic sensitivity patterns in cystic fibrosis. Pediatr Pulmonol. 2003; 35:463–466. © 2003 Wiley‐Liss, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>12746944</pmid><doi>10.1002/ppul.10294</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 8755-6863 |
| ispartof | Pediatric pulmonology, 2003-06, Vol.35 (6), p.463-466 |
| issn | 8755-6863 1099-0496 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_73302205 |
| source | Wiley-Blackwell Read & Publish Collection |
| subjects | Adolescent Antibacterial agents antibiotic sensitivity Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences cystic fibrosis Cystic Fibrosis - complications Cystic Fibrosis - drug therapy Cystic Fibrosis - microbiology Drug Resistance, Microbial Humans Male Medical sciences Microbial Sensitivity Tests - methods microbiology Pharmacology. Drug treatments Pseudomonas aeruginosa Pseudomonas aeruginosa - drug effects Pseudomonas Infections - drug therapy Respiratory Therapy sputum Sputum - microbiology |
| title | Clinical application of direct sputum sensitivity testing in a severe infective exacerbation of cystic fibrosis |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-04T04%3A48%3A56IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Clinical%20application%20of%20direct%20sputum%20sensitivity%20testing%20in%20a%20severe%20infective%20exacerbation%20of%20cystic%20fibrosis&rft.jtitle=Pediatric%20pulmonology&rft.au=Serisier,%20David%20J.&rft.date=2003-06&rft.volume=35&rft.issue=6&rft.spage=463&rft.epage=466&rft.pages=463-466&rft.issn=8755-6863&rft.eissn=1099-0496&rft.coden=PEPUES&rft_id=info:doi/10.1002/ppul.10294&rft_dat=%3Cproquest_cross%3E73302205%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c3934-6c9e937f49f873433a5a4324dc0e30952e37c10fdbbc13bf5397bf29990b17ce3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=73302205&rft_id=info:pmid/12746944&rfr_iscdi=true |