The critical role of adenosine A2A receptors in downregulation of inflammation and immunity in the pathogenesis of infectious diseases

Adenosine can be described as a retaliatory metabolite, the production and release of which is usually enhanced under adverse environmental conditions. Binding via specific receptors, adenosine activates endogenous protective mechanisms aiming at the restoration of tissue homeostasis. While adenosin...

Full description

Saved in:
Bibliographic Details
Published in:Microbes and infection 2003-05, Vol.5 (6), p.515-526
Main Authors: THIEL, Manfred, CALDWELL, Charles C, SITKOVSKY, Michail V
Format: Article
Language:English
Subjects:
Adenosine - metabolism
Animals
Biological and medical sciences
Communicable Diseases - immunology
Communicable Diseases - metabolism
Communicable Diseases - pathology
General aspects
Humans
Immunity, Innate
Infection pathogenesis
Infectious diseases
Inflammation - immunology
Inflammation - pathology
Medical sciences
Receptor, Adenosine A2A
Receptors, Purinergic P1 - metabolism
Sepsis - immunology
Sepsis - metabolism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Adenosine can be described as a retaliatory metabolite, the production and release of which is usually enhanced under adverse environmental conditions. Binding via specific receptors, adenosine activates endogenous protective mechanisms aiming at the restoration of tissue homeostasis. While adenosinergic downregulation of tissue damage is beneficial in acute inflammation, chronic suppression of the immune system by adenosine may account for immunoparalysis in long-term septic patients.
ISSN:1286-4579
1769-714X
DOI:10.1016/s1286-4579(03)00068-6