Effect of carvedilol on exercise tolerance in patients with chronic heart failure and a restrictive left ventricular filling pattern

In chronic heart failure, carvedilol induced subjective improvement in functional capacity (New York Heart Association class) that was not paralleled by objective changes in cardiopulmonary indexes. However, the presence of a restrictive left ventricular filling pattern and/or lower exercise toleran...

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Bibliographic Details
Published in:The American journal of cardiology 2003-05, Vol.91 (10), p.1281-1283
Main Authors: Al-Nasser, Faisal, Yousufuddin, Mohamed, Al-Nozha, Farid, Anker, Stefan D., Coats, Andrew J.S., Piepoli, Massimo F., Ponikowski, Piotr P.
Format: Article
Language:English
Subjects:
Analysis of Variance
Antihypertensive Agents - pharmacology
Antihypertensive Agents - therapeutic use
Biological and medical sciences
Blood Pressure - drug effects
Carbazoles - pharmacology
Carbazoles - therapeutic use
Cardiovascular disease
Cardiovascular system
Carvedilol
Chronic illnesses
Dose-Response Relationship, Drug
Echocardiography, Doppler, Pulsed
Effects
Exercise
Exercise Test - methods
Exercise Tolerance - drug effects
Female
Heart Failure - diagnostic imaging
Heart Failure - drug therapy
Heart Rate - drug effects
Heart Ventricles - diagnostic imaging
Humans
Male
Medical sciences
Middle Aged
Miscellaneous
Oxygen Consumption - drug effects
Patients
Pharmacology. Drug treatments
Propanolamines - pharmacology
Propanolamines - therapeutic use
Stroke Volume - drug effects
Treatment Outcome
Ventricular Dysfunction, Left - diagnostic imaging
Ventricular Dysfunction, Left - drug therapy
Ventricular Function, Left - drug effects
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Description
Summary:In chronic heart failure, carvedilol induced subjective improvement in functional capacity (New York Heart Association class) that was not paralleled by objective changes in cardiopulmonary indexes. However, the presence of a restrictive left ventricular filling pattern and/or lower exercise tolerance may identify subgroups of patients in whom carvedilol may be particularly effective also in improving exercise capacity.
ISSN:0002-9149
1879-1913
DOI:10.1016/S0002-9149(03)00287-X