Hallmarks of Caenorhabditis elegans N-glycosylation: complexity and controversy

Caenorhabditis elegans has become one of the most widely used model organisms for a range of molecular cell biological applications and is being increasingly used by glycobiologists. However, a major problem has been the lack of knowledge of the structure of the protein-linked glycans from this orga...

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Bibliographic Details
Published in:Biochimie 2003-01, Vol.85 (1), p.25-32
Main Authors: Haslam, S.M, Dell, A
Format: Article
Language:English
Subjects:
Animals
C. elegans
Caenorhabditis elegans - chemistry
Caenorhabditis elegans - metabolism
Glycome
Glycosylation
Magnetic Resonance Spectroscopy
Mass Spectrometry - methods
Molecular Structure
N-glycans
Polysaccharides - chemistry
Polysaccharides - classification
Polysaccharides - isolation & purification
Structure
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Summary:Caenorhabditis elegans has become one of the most widely used model organisms for a range of molecular cell biological applications and is being increasingly used by glycobiologists. However, a major problem has been the lack of knowledge of the structure of the protein-linked glycans from this organism. In recent years several groups have published structural data, particularly N-glycan structural data. However, some of these data are contradictory. In this review we critically assess all the N-glycan structural data and consider how close we are in our goal of defining the glycome of C. elegans.
ISSN:0300-9084
1638-6183
DOI:10.1016/S0300-9084(03)00041-5