Topical palmitoyl pentapeptide provides improvement in photoaged human facial skin

• Published in: International journal of cosmetic science 2005-06, Vol.27 (3), p.155-160
• Main Authors: Robinson, L. R., Fitzgerald, N. C., Doughty, D. G., Dawes, N. C., Berge, C. A., Bissett, D. L.
• Format: Article
• Language: English
• Subjects: aging; Biological and medical sciences; Dermatology; Diseases of the skin. Cosmetics; Medical sciences; pal-KTTKS; peptide; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects); Skin involvement in other diseases. Miscellaneous. General aspects; texture; wrinkling
• ISSN: 0142-5463; 1468-2494
• DOI: 10.1111/j.1467-2494.2005.00261.x

The palmitoyl pentapeptide palmitoyl-lysine-threonine-threonine-lysine-serine (pal-KTTKS) is a synthetic material that was designed as a topical agent to stimulate collagen production and thus provide a skin anti-wrinkle benefit. To determine if pal-KTTKS is effective, the clinical study reported here was conducted. Caucasian female subjects (n = 93, aged 35-55) participated in a 12-week, double-blind, placebo-controlled, split-face, left-right randomized clinical study assessing two topical products: moisturizer control product vs. the same moisturizer product containing 3 ppm pal-KTTKS. Pal-KTTKS was well tolerated by the skin and provided significant improvement vs. placebo control for reduction in wrinkles/fine lines by both quantitative technical and expert grader image analysis. In self-assessments, subjects also reported significant fine line/wrinkle improvements and noted directional effects for other facial improvement parameters.