Antimalarial Dihydroisocoumarins Produced by Geotrichum sp., an Endophytic Fungus of Crassocephalum crepidioides

Three novel dihydroisocoumarin derivatives (1-3) with antimalarial, antituberculous, and antifungal activities have been isolated by bioassay-guided fractionation from an endophytic fungus, Geotrichum sp., collected from Crassocephalum crepidioides. Structures were established as 7-butyl-6,8-dihydro...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2003-05, Vol.66 (5), p.709-711
Main Authors: KONGSAEREE, Palangpon, PRABPAI, Samran, SRIUBOLMAS, Nongluksna, VONGVEIN, Chanika, WIYAKRUTTA, Suthep
Format: Article
Language:English
Subjects:
Animals
Antibiotics (antibacterial agents, antifungal agents)
Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents
Antifungal Agents - chemistry
Antifungal Agents - isolation & purification
Antifungal Agents - pharmacology
Antimalarials - chemistry
Antimalarials - isolation & purification
Antimalarials - pharmacology
Antitubercular Agents - chemistry
Antitubercular Agents - isolation & purification
Antitubercular Agents - pharmacology
Applied microbiology
Biological and medical sciences
Candida albicans - drug effects
Coumarins - chemistry
Coumarins - isolation & purification
Coumarins - pharmacology
Fundamental and applied biological sciences. Psychology
Geotrichum - chemistry
Microbiology
Molecular Structure
Mycobacterium tuberculosis - drug effects
Nuclear Magnetic Resonance, Biomolecular
Plasmodium falciparum - drug effects
Stereoisomerism
Thailand
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Summary:Three novel dihydroisocoumarin derivatives (1-3) with antimalarial, antituberculous, and antifungal activities have been isolated by bioassay-guided fractionation from an endophytic fungus, Geotrichum sp., collected from Crassocephalum crepidioides. Structures were established as 7-butyl-6,8-dihydroxy-3(R)-pent-11-enylisochroman-1-one (1), 7-but-15-enyl-6,8-dihydroxy-3(R)-pent-11-enylisochroman-1-one (2), and 7-butyl-6,8-dihydroxy-3(R)-pentylisochroman-1-one (3) using spectroscopic data.
ISSN:0163-3864
1520-6025
DOI:10.1021/np0205598