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Antimalarial Dihydroisocoumarins Produced by Geotrichum sp., an Endophytic Fungus of Crassocephalum crepidioides

Three novel dihydroisocoumarin derivatives (1-3) with antimalarial, antituberculous, and antifungal activities have been isolated by bioassay-guided fractionation from an endophytic fungus, Geotrichum sp., collected from Crassocephalum crepidioides. Structures were established as 7-butyl-6,8-dihydro...

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Published in:	Journal of natural products (Washington, D.C.) D.C.), 2003-05, Vol.66 (5), p.709-711
Main Authors:	KONGSAEREE, Palangpon, PRABPAI, Samran, SRIUBOLMAS, Nongluksna, VONGVEIN, Chanika, WIYAKRUTTA, Suthep
Format:	Article
Language:	English
Subjects:	Animals Antibiotics (antibacterial agents, antifungal agents) Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents Antifungal Agents - chemistry Antifungal Agents - isolation & purification Antifungal Agents - pharmacology Antimalarials - chemistry Antimalarials - isolation & purification Antimalarials - pharmacology Antitubercular Agents - chemistry Antitubercular Agents - isolation & purification Antitubercular Agents - pharmacology Applied microbiology Biological and medical sciences Candida albicans - drug effects Coumarins - chemistry Coumarins - isolation & purification Coumarins - pharmacology Fundamental and applied biological sciences. Psychology Geotrichum - chemistry Microbiology Molecular Structure Mycobacterium tuberculosis - drug effects Nuclear Magnetic Resonance, Biomolecular Plasmodium falciparum - drug effects Stereoisomerism Thailand
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container_issue	5
container_start_page	709
container_title	Journal of natural products (Washington, D.C.)
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creator	KONGSAEREE, Palangpon PRABPAI, Samran SRIUBOLMAS, Nongluksna VONGVEIN, Chanika WIYAKRUTTA, Suthep
description	Three novel dihydroisocoumarin derivatives (1-3) with antimalarial, antituberculous, and antifungal activities have been isolated by bioassay-guided fractionation from an endophytic fungus, Geotrichum sp., collected from Crassocephalum crepidioides. Structures were established as 7-butyl-6,8-dihydroxy-3(R)-pent-11-enylisochroman-1-one (1), 7-but-15-enyl-6,8-dihydroxy-3(R)-pent-11-enylisochroman-1-one (2), and 7-butyl-6,8-dihydroxy-3(R)-pentylisochroman-1-one (3) using spectroscopic data.
doi_str_mv	10.1021/np0205598
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source	American Chemical Society:Jisc Collections:American Chemical Society Read & Publish Agreement 2022-2024 (Reading list)
subjects	Animals Antibiotics (antibacterial agents, antifungal agents) Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents Antifungal Agents - chemistry Antifungal Agents - isolation & purification Antifungal Agents - pharmacology Antimalarials - chemistry Antimalarials - isolation & purification Antimalarials - pharmacology Antitubercular Agents - chemistry Antitubercular Agents - isolation & purification Antitubercular Agents - pharmacology Applied microbiology Biological and medical sciences Candida albicans - drug effects Coumarins - chemistry Coumarins - isolation & purification Coumarins - pharmacology Fundamental and applied biological sciences. Psychology Geotrichum - chemistry Microbiology Molecular Structure Mycobacterium tuberculosis - drug effects Nuclear Magnetic Resonance, Biomolecular Plasmodium falciparum - drug effects Stereoisomerism Thailand
title	Antimalarial Dihydroisocoumarins Produced by Geotrichum sp., an Endophytic Fungus of Crassocephalum crepidioides
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