Reduced endothelial progenitor cells and brachial artery flow‐mediated dilation as evidence of endothelial dysfunction in ocular hypertension and primary open‐angle glaucoma

. Purpose:  This study aimed to assess vascular endothelial function in patients with ocular hypertension (OHT) or primary open‐angle glaucoma (POAG) by measuring: (a) endothelium‐dependent flow‐mediated vasodilation (FMD) of the brachial artery, and (b) circulating endothelial progenitor cells, whi...

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Published in:Acta ophthalmologica (Oxford, England) England), 2010-02, Vol.88 (1), p.135-141
Main Authors: Fadini, Gian Paolo, Pagano, Claudio, Baesso, Ilenia, Kotsafti, Olympia, Doro, Daniele, De Kreutzenberg, Saula V., Avogaro, Angelo, Agostini, Carlo, Dorigo, Maria T.
Format: Article
Language:English
Subjects:
Adult
Brachial Artery - physiopathology
Cell Count
endothelial dysfunction
endothelial progenitor cells
Endothelium, Vascular - pathology
Endothelium, Vascular - physiopathology
Female
glaucoma pathogenesis
Glaucoma, Open-Angle - pathology
Glaucoma, Open-Angle - physiopathology
Humans
Male
Middle Aged
Ocular Hypertension - pathology
Ocular Hypertension - physiopathology
Regional Blood Flow
Stem Cells - pathology
vascular risk
Vasodilation
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Summary:. Purpose:  This study aimed to assess vascular endothelial function in patients with ocular hypertension (OHT) or primary open‐angle glaucoma (POAG) by measuring: (a) endothelium‐dependent flow‐mediated vasodilation (FMD) of the brachial artery, and (b) circulating endothelial progenitor cells, which are believed to support the integrity of the vascular endothelium. Methods:  We enrolled 25 patients with OHT, 23 with POAG and 26 control subjects, all of whom were aged
ISSN:1755-375X
1755-3768
DOI:10.1111/j.1755-3768.2009.01573.x