Pregnancy and childbirth in carriers of the lamin A/C-gene mutation

This retrospective case report describes 11 pregnancies in five women. All of the women were carriers of the lamin A/C gene mutation known to cause dilated cardiomyopathy, often together with atrioventricular conduction disturbances. The penetrance of these mutations is age‐dependent but almost comp...

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Bibliographic Details
Published in:European journal of heart failure 2010-06, Vol.12 (6), p.630-633
Main Authors: Palojoki, Eeva, Kaartinen, Maija, Kaaja, Risto, Reissell, Eeva, Kärkkäinen, Satu, Kuusisto, Johanna, Heliö, Tiina
Format: Article
Language:English
Subjects:
Adult
Cardiomyopathy
Cardiomyopathy, Dilated - genetics
Female
Humans
Lamin A/C mutations
Lamin Type A - genetics
Middle Aged
Mutation
Pregnancy
Pregnancy Complications, Cardiovascular - genetics
Retrospective Studies
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Summary:This retrospective case report describes 11 pregnancies in five women. All of the women were carriers of the lamin A/C gene mutation known to cause dilated cardiomyopathy, often together with atrioventricular conduction disturbances. The penetrance of these mutations is age‐dependent but almost complete. We found no major adverse effects or worsening in the cardiac condition during or after the pregnancy in these patients. All babies were healthy except for one with a small ventricular septal defect, one diagnosed with tracheobronchomalasia, and one with a patent ductus arteriosus. None of these defects have been associated with lamin A/C mutations.
ISSN:1388-9842
1879-0844
DOI:10.1093/eurjhf/hfq059