A pilot study assessing the role of 25 hydroxy vitamin D levels in patients with vitiligo vulgaris

Background Very low vitamin D levels have been noted in patients with a variety of autoimmune diseases. Objective To determine whether low vitamin D levels are associated with autoimmunity in the setting of vitiligo vulgaris. Methods A prospective cohort study was conducted on 45 consecutive patient...

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Bibliographic Details
Published in:Journal of the American Academy of Dermatology 2010-06, Vol.62 (6), p.937-941
Main Authors: Silverberg, Jonathan I., MD, PhD, MPH, Silverberg, Arnold I., MD, Malka, Edmond, MPH, CPH, CSci, CChem, MRSC, FAIC, Silverberg, Nanette B., MD
Format: Article
Language:English
Subjects:
25 (OH) vitamin D
Adolescent
Adult
Aged
Autoimmune Diseases - blood
autoimmunity
Biological and medical sciences
Child
Child, Preschool
Dermatology
Female
Humans
hypopigmentation
Male
Medical sciences
Middle Aged
Pigmentary diseases of the skin
Pilot Projects
Skin Pigmentation
Vitamin D - analogs & derivatives
Vitamin D - blood
Vitamin D Deficiency - complications
Vitamin D Deficiency - immunology
Vitiligo - blood
Vitiligo - ethnology
Vitiligo - etiology
Vitiligo - immunology
vitiligo vulgaris
Young Adult
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Summary:Background Very low vitamin D levels have been noted in patients with a variety of autoimmune diseases. Objective To determine whether low vitamin D levels are associated with autoimmunity in the setting of vitiligo vulgaris. Methods A prospective cohort study was conducted on 45 consecutive patients with vitiligo vulgaris. 25-Hydroxyvitamin D levels were determined from sera collected at the time of study enrollment. Logistic regression analysis of the relationship of 25-hydroxyvitamin D levels to disease state was performed, including surface area, recent-onset vitiligo, Fitzpatrick skin type and ethnicity, dairy intake, and both personal and family history of autoimmunity. Multiple univariate and multivariate logistic regression models were developed to assess the interrelationship of these parameters. Results 25-Hydroxyvitamin D levels were divided into 3 groups: 31.1% were normal (>30 ng/mL), 55.6% were insufficient (
ISSN:0190-9622
1097-6787
DOI:10.1016/j.jaad.2009.11.024