Renal cortical necrosis at presentation in a patient with systemic lupus erythematosus: an autopsy case report

Systemic lupus erythematosus (SLE) is a multisystemic autoimmune disorder. Renal involvement has the worst prognosis. However, renal cortical necrosis is extremely unusual in SLE. In this case report, we describe the autopsy findings in a young female patient with SLE presenting with renal failure....

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Bibliographic Details
Published in:Clinical rheumatology 2010-07, Vol.29 (7), p.815-818
Main Authors: Uppin, Megha S, Rajasekhar, Liza, Swetha, H, Srinivasan, V. R, Prayaga, Aruna K
Format: Article
Language:English
Subjects:
Autopsy
CAPS
Case Report
Female
Humans
Kidney Cortex Necrosis - complications
Kidney Cortex Necrosis - pathology
Lupus Erythematosus, Systemic - complications
Lupus Erythematosus, Systemic - pathology
Medicine
Medicine & Public Health
Renal cortical necrosis
Renal Insufficiency - complications
Renal Insufficiency - mortality
Rheumatology
SLE
Young Adult
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Summary:Systemic lupus erythematosus (SLE) is a multisystemic autoimmune disorder. Renal involvement has the worst prognosis. However, renal cortical necrosis is extremely unusual in SLE. In this case report, we describe the autopsy findings in a young female patient with SLE presenting with renal failure. At autopsy, there was Libmann-Sacks endocarditis with multiorgan infarcts and renal cortical necrosis. Secondary antiphospholipid antibodies contribute to the cardiac and renal manifestations in SLE. We discuss the incidence and pathogenesis of endocarditis with differential diagnosis for cortical necrosis in a patient of SLE.
ISSN:0770-3198
1434-9949
DOI:10.1007/s10067-010-1395-5