Biotransformation of α-Cedrol and Caryophyllene Oxide by the Fungus Neurospora crassa

Incubation of α-cedrol and caryophyllene oxide with Neurospora crassa afforded 12β-hydroxy cedrol, 10α-hydroxy cedrol, and 3β-hydroxy cedrol, and 12β-hydroxy caryophyllene oxide as major metabolites, respectively. The antibacterial and radical scavenging activities of the metabolites were evaluated...

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Bibliographic Details
Published in:Natural product communications 2010-04, Vol.5 (4), p.515-518
Main Authors: Kiran, Ismail, Durceylan, Zeynep, Kirimer, Neşe, Başer, K. Hüsnü Can, Noma, Yoshiaki, Demirci, Fatih
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - metabolism
Anti-Bacterial Agents - pharmacology
Biotransformation
Biphenyl Compounds - chemistry
Free Radical Scavengers - chemistry
Free Radical Scavengers - metabolism
Free Radical Scavengers - pharmacology
Microbial Sensitivity Tests
Neurospora crassa - metabolism
Picrates - chemistry
Sesquiterpenes - chemistry
Sesquiterpenes - metabolism
Sesquiterpenes - pharmacology
Terpenes - chemistry
Terpenes - metabolism
Terpenes - pharmacology
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Summary:Incubation of α-cedrol and caryophyllene oxide with Neurospora crassa afforded 12β-hydroxy cedrol, 10α-hydroxy cedrol, and 3β-hydroxy cedrol, and 12β-hydroxy caryophyllene oxide as major metabolites, respectively. The antibacterial and radical scavenging activities of the metabolites were evaluated in vitro using broth microdilution and bioauthographic techniques. However, no significant antibacterial and antioxidant activities were observed when compared with those of standard substances.
ISSN:1934-578X
1555-9475
DOI:10.1177/1934578X1000500403