Neurosyphilis in the patients with and without HIV infection: description and comparison of two historical cohorts

Neurosyphilis follows a more aggressive and different clinical course in HIV-infected patients compared to patients with normal immunity. Two historical series of patients with a diagnosis of neurosyphilis between 1995 and 2008 were compared: they included a group of 15 patients with y and 28 patien...

Full description

Saved in:
Bibliographic Details
Published in:Revista chilena de infectología 2009-12, Vol.26 (6), p.540-547
Main Authors: Lasso, Martín B, Balcells M, M Elvira M, Fernández, Ana S, Gaete, Pablo G, Serri, Michel V, Pérez, Jorge G, Chain, Carolina A, Cerón, Inés A, Duque, Clara O, Ramírez, Anamaría B
Format: Article
Language:Spanish
Subjects:
Adult
Aged
AIDS-Related Opportunistic Infections - complications
AIDS-Related Opportunistic Infections - diagnosis
AIDS-Related Opportunistic Infections - drug therapy
Anti-Bacterial Agents
Cohort Studies
Female
HIV Seronegativity
Humans
Male
Middle Aged
Neurosyphilis - complications
Neurosyphilis - diagnosis
Neurosyphilis - drug therapy
Penicillin G Benzathine - therapeutic use
Retrospective Studies
Syphilis Serodiagnosis
Young Adult
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Neurosyphilis follows a more aggressive and different clinical course in HIV-infected patients compared to patients with normal immunity. Two historical series of patients with a diagnosis of neurosyphilis between 1995 and 2008 were compared: they included a group of 15 patients with y and 28 patients without HIV infection. Probability of neurosyphilis in patients with positive serum VDRL was increased in patients infected with HIV compared to HIV negative patients (OR: 62.37 IC:95% (32.1-119.1) p value:< 0,001). Predominant clinical manifestations in neurosyphilis in the HIV negative group were ocular abnormality, vascular encephalic and spinal cord lesions. In the HIV positive group, they were fever, ocular abnormalities and headache. There were no differences in cerebrospinal fluid characteristics between both groups. Neurosyphilis was diagnosed even in patients with blood VDRL of < 1:32, that happened in 17.8% of the HIV positive patients with blood and in 60% of t he HIV negative patients. Penicillin sodium given at dose >or= than 18.000.000 IU/day IV during 14 days was the most common treatment. In patients with clinical neurosyphilis, 93% of HIV negative group, and 54.2% of HIV positive group had persistent neurological after-effects. Three HIV positive patients died due to causes not related to neurosyphilis.
ISSN:0716-1018