Antiproliferative Activity of Withanolides against Human Breast Cancer Cell Lines

The in vitro antiproliferative activity of a series of 22 naturally occurring withanolides was examined against the T-47D, MCF7, MCF7/BUS, MDA-MB-231, and SK-Br-3 human solid tumor breast cancer cell lines. The most active compound showed GI50 values in the range 0.16−0.71 μM. The aromatic withanoli...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2010-05, Vol.73 (5), p.966-968
Main Authors: Machin, Rubén P, Veleiro, Adriana S, Nicotra, Viviana E, Oberti, Juan C, M. Padrón, José
Format: Article
Language:English
Subjects:
Antineoplastic agents
Antineoplastic Agents, Phytogenic - chemistry
Antineoplastic Agents, Phytogenic - pharmacology
Biological and medical sciences
Breast Neoplasms - pathology
Cell Line, Tumor
Combinatorial Chemistry Techniques
Drug Screening Assays, Antitumor
Female
General aspects
General pharmacology
Humans
Medical sciences
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Structure-Activity Relationship
Withanolides - chemistry
Withanolides - pharmacology
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Summary:The in vitro antiproliferative activity of a series of 22 naturally occurring withanolides was examined against the T-47D, MCF7, MCF7/BUS, MDA-MB-231, and SK-Br-3 human solid tumor breast cancer cell lines. The most active compound showed GI50 values in the range 0.16−0.71 μM. The aromatic withanolide 19 exhibited specific activity for the estrogen-receptor-positive cell lines (T-47D, MCF7, and MCF7/BUS). Overall, the results demonstrated the relevance of the substitution pattern on the A and B rings on the resultant antiproliferative activity.
ISSN:0163-3864
1520-6025
DOI:10.1021/np9006734