Reproducibility of callosal effects of transcranial magnetic stimulation (TMS) with interhemispheric paired pulses

Transcranial magnetic stimulation (TMS) of the motor cortex of one hemisphere (conditioning stimulus (CS)) inhibits EMG responses evoked in distal hand muscles by a later magnetic stimulus given at an appropriate interval, over the opposite hemisphere (test stimulus (TS)). This effect is commonly at...

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Bibliographic Details
Published in:Neuroscience research 2003-06, Vol.46 (2), p.219-227
Main Authors: De Gennaro, Luigi, Ferrara, Michele, Bertini, Mario, Pauri, Flavia, Cristiani, Riccardo, Curcio, Giuseppe, Romei, Vincenzo, Fratello, Fabiana, Rossini, Paolo Maria
Format: Article
Language:English
Subjects:
Adult
Conditioning (Psychology) - physiology
Corpus Callosum - physiology
Electric Stimulation
Electromyography
Evoked Potentials, Motor - physiology
Female
Functional Laterality
Hand - innervation
Humans
Inter- and intra-individual variability
Male
Motor Cortex - physiology
Motor evoked potentials
Muscle, Skeletal - physiology
Neural Inhibition - physiology
Paired-pulse technique
Reproducibility
Reproducibility of Results
Transcallosal inhibition
Transcranial Magnetic Stimulation
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Summary:Transcranial magnetic stimulation (TMS) of the motor cortex of one hemisphere (conditioning stimulus (CS)) inhibits EMG responses evoked in distal hand muscles by a later magnetic stimulus given at an appropriate interval, over the opposite hemisphere (test stimulus (TS)). This effect is commonly attributed to an inhibition produced at cortical level via a transcallosal route. The present study assessed the reproducibility of the transcallosal inhibition effects in different sessions in healthy subjects. Within- and between-subject variability, relating to interhemispheric differences was also evaluated. A magnetic CS on one hemisphere effectively inhibited EMG responses of the abductor digiti minimi stimulated by a TS delivered over the opposite hemisphere in a range of intervals centered at 12 ms. Even though group effects were reproduced in separate sessions, the high between- and within-subject variability yielded low test–retest correlations. This differentiation forces the definition of reproducibility (or repeatability), as the replication of the same mean curves of EMG reduction, and of reliability, as the between- or within-subject correlations between values of specific EMG measures.
ISSN:0168-0102
1872-8111
DOI:10.1016/S0168-0102(03)00060-9