3,3′,4,5,5′-pentahydroxy- trans-stilbene, a resveratrol derivative, induces apoptosis in colorectal carcinoma cells via oxidative stress

Resveratrol exhibits anti-tumor properties against different types of cancer. In this study, several polyhydroxylated resveratrol derivatives were prepared with the aim of discovering new leading compounds with clinical potential for human colon cancer chemotherapy. Among these compounds, 3,3′,4,5,5...

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Bibliographic Details
Published in:European journal of pharmacology 2010-07, Vol.637 (1), p.55-61
Main Authors: Li, Haitao, Wu, William Ka Kei, Zheng, Zongping, Che, Chun Tao, Li, Zhi Jie, Xu, Dan Dan, Wong, Clover Ching Man, Ye, Cai Guo, Sung, Joseph Jao Yiu, Cho, Chi Hin, Wang, Mingfu
Format: Article
Language:English
Subjects:
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Apoptosis
Apoptosis - drug effects
Biological and medical sciences
Blotting, Western
Colon cancer
Colorectal Neoplasms - metabolism
Colorectal Neoplasms - pathology
Cytoplasm - metabolism
DNA Fragmentation - drug effects
Enzyme-Linked Immunosorbent Assay
Gastroenterology. Liver. Pancreas. Abdomen
Glutathione - metabolism
HT29 Cells
Humans
Hydroxylated resveratrol derivative
Medical sciences
Nucleosomes - metabolism
Oxidative stress
Oxidative Stress - drug effects
Pharmacology. Drug treatments
Poly(ADP-ribose) Polymerases - metabolism
Stilbenes - chemistry
Stilbenes - pharmacology
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Tumor Cells, Cultured
Tumors
Up-Regulation - drug effects
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Summary:Resveratrol exhibits anti-tumor properties against different types of cancer. In this study, several polyhydroxylated resveratrol derivatives were prepared with the aim of discovering new leading compounds with clinical potential for human colon cancer chemotherapy. Among these compounds, 3,3′,4,5,5′-pentahydroxy- trans-stilbene (PHS) displayed the most potent cytotoxicity and triggered apoptosis in HT-29 cells as evidenced by increased poly(ADP-ribose) polymerase (PARP) cleavage, elevated levels of cytoplasmic nucleosomes and DNA fragmentation. Further mechanistic analysis revealed that PHS-induced apoptosis was caspase-dependent and mediated by its pro-oxidative action through up-regulation of reactive oxidative species generation and depletion of intracellular glutathione.
ISSN:0014-2999
1879-0712
DOI:10.1016/j.ejphar.2010.04.009