A structural classification of substrate-binding proteins

Substrate-binding proteins (SBP) are associated with a wide variety of protein complexes. The proteins are part of ATP-binding cassette transporters for substrate uptake, ion gradient driven transporters, DNA-binding proteins, as well as channels and receptors from both pro- and eukaryotes. A wealth...

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Bibliographic Details
Published in:FEBS letters 2010-06, Vol.584 (12), p.2606-2617
Main Authors: Berntsson, Ronnie P.-A., Smits, Sander H.J., Schmitt, Lutz, Slotboom, Dirk-Jan, Poolman, Bert
Format: Article
Language:English
Subjects:
Animals
ATP-binding cassette transporter
Carrier Proteins - chemistry
Carrier Proteins - classification
Databases, Protein
Ligand receptor
Membrane Proteins - chemistry
Models, Molecular
Multiprotein Complexes - chemistry
Protein Conformation
Signal Transduction
Structural classification
Substrate-binding protein
Tripartite ATP-independent periplasmic transporter
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Summary:Substrate-binding proteins (SBP) are associated with a wide variety of protein complexes. The proteins are part of ATP-binding cassette transporters for substrate uptake, ion gradient driven transporters, DNA-binding proteins, as well as channels and receptors from both pro- and eukaryotes. A wealth of structural and functional data is available on SBPs, with over 120 unique entries in the Protein Data Bank (PDB). Over a decade ago these proteins were divided into three structural classes, but based on the currently available wealth of structural data, we propose a new classification into six clusters, based on features of their three-dimensional structure.
ISSN:0014-5793
1873-3468
DOI:10.1016/j.febslet.2010.04.043