Beneficial Effects of Cinnamon Proanthocyanidins on the Formation of Specific Advanced Glycation Endproducts and Methylglyoxal-Induced Impairment on Glucose Consumption

• Published in: Journal of agricultural and food chemistry 2010-06, Vol.58 (11), p.6692-6696
• Main Authors: Peng, Xiaofang, Ma, Jinyu, Chao, Jianfei, Sun, Zheng, Chang, Raymond Chuen-Chung, Tse, Iris, Li, Edmund T. S, Chen, Feng, Wang, Mingfu
• Format: Article
• Language: English
• Subjects: adipocytes; Adipocytes - drug effects; Adipocytes - metabolism; Animals; antioxidant activity; Aroma and flavouring agent industries; bark; Bioactive Constituents; biochemical pathways; Biological and medical sciences; carbohydrate metabolism; carbonyl compounds; carboxymethyl lysine; catechin; cell communication; Cinnamomum zeylanicum - chemistry; cinnamon; epicatechin; Food industries; free radical scavengers; Fundamental and applied biological sciences. Psychology; glucose; Glucose - metabolism; glycation; Glycation End Products, Advanced - metabolism; Glycosylation - drug effects; human nutrition; insulin; methylglyoxal; Mice; Models, Biological; NIH 3T3 Cells; pentosidine; phytochemicals; Plant Extracts - pharmacology; proanthocyanidins; Proanthocyanidins - pharmacology; procyanidin; protective effect; Pyruvaldehyde - pharmacology
• ISSN: 0021-8561; 1520-5118
• DOI: 10.1021/jf100538t

Advanced glycation endproducts (AGEs) are a group of complex and heterogeneous compounds formed from nonenzymatic reactions. The accumulation of AGEs in vivo has been implicated as a major pathogenic process in diabetic complications and other health disorders, such as atherosclerosis and Alzheimer’s disease, and normal aging. In this study, we investigate the inhibitory effects of cinnamon bark proanthocyanidins, catechin, epicatechin, and procyanidin B2 on the formation of specific AGE representatives including pentosidine, N ε-(carboxymethyl)lysine (CML), and methylglyoxal (MGO) derived AGEs. These compounds displayed obvious inhibitory effects on these specific AGEs, which are largely attributed to both their antioxidant activities and carbonyl scavenging capacities. Meanwhile, in terms of their potent MGO scavenging capacities, effects of these proanthocyanidins on insulin signaling pathways interfered by MGO were evaluated in 3T3-L1 adipocytes. According to the results, proanthocyanidins exerted protective effects on glucose consumption impaired by MGO in 3T3-L1 fat cells.