Infrared spectroscopy indicates altered bone turnover and remodeling activity in renal osteodystrophy

Renal osteodystrophy alters metabolic activity and remodeling rate of bone and also may lead to different bone composition. The objective of this study was to characterize the composition of bone in high‐turnover renal osteodystrophy patients by means of Fourier transform infrared spectroscopic imag...

Full description

Saved in:
Bibliographic Details
Published in:Journal of bone and mineral research 2010-06, Vol.25 (6), p.1360-1366
Main Authors: Isaksson, Hanna, Turunen, Mikael J, Rieppo, Lassi, Saarakkala, Simo, Tamminen, Inari S, Rieppo, Jarno, Kröger, Heikki, Jurvelin, Jukka S
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Biopsy
Bone and Bones - pathology
Bone and Bones - physiopathology
bone composition
Bone Remodeling - physiology
carbonate
Chronic Kidney Disease-Mineral and Bone Disorder - pathology
Chronic Kidney Disease-Mineral and Bone Disorder - physiopathology
fourier transform
Fundamental and applied biological sciences. Psychology
histomorphometry
Humans
infrared
Male
renal osteodystrophy
Skeleton and joints
Spectroscopy, Fourier Transform Infrared
Vertebrates: osteoarticular system, musculoskeletal system
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Renal osteodystrophy alters metabolic activity and remodeling rate of bone and also may lead to different bone composition. The objective of this study was to characterize the composition of bone in high‐turnover renal osteodystrophy patients by means of Fourier transform infrared spectroscopic imaging (FTIRI). Iliac crest biopsies from healthy bone (n = 11) and patients with renal osteodystrophy (ROD, n = 11) were used in this study. The ROD samples were from patients with hyperparathyroid disease. By using FTIRI, phosphate‐to‐amide I ratio (mineral‐to‐matrix ratio), carbonate‐to‐phosphate ratio, and carbonate‐to‐amide I ratio (turnover rate/remodeling activity), as well as the collagen cross‐link ratio (collagen maturity), were quantified. Histomorphometric analyses were conducted for comparison. The ROD samples showed significantly lower carbonate‐to‐phosphate (p 
ISSN:0884-0431
1523-4681
DOI:10.1002/jbmr.10