Leukocyte telomere length is inversely correlated with plasma Von Willebrand factor

Abstract Introduction Leukocyte telomere length (LTL) is short, while the plasma level of Von Willebrand (VWF) is high in persons with atherosclerosis. Moreover, both short LTLs and high VWF levels are observed in individuals who display risks for atherosclerosis, including hypertension, obesity, in...

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Published in:Thrombosis research 2010-06, Vol.125 (6), p.e339-e342
Main Authors: Hjelmborg, Jacob v.B, Nzietchueng, Rosine, Kimura, Masayuki, Gardner, Jeffrey P, Bladbjerg, Else M, Christensen, Kaare, Aviv, Abraham, Benetos, Athanase
Format: Article
Language:English
Subjects:
Adult
Age Factors
Aged
Aged, 80 and over
Atherosclerosis
Blood Coagulation
Cohort Studies
Data Collection
Female
Hematology, Oncology and Palliative Medicine
Humans
Hypertension
Leukocytes - cytology
Male
Middle Aged
Regression Analysis
Sex Factors
Telomere
Telomere - ultrastructure
Von Willebrand factor
von Willebrand Factor - analysis
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Summary:Abstract Introduction Leukocyte telomere length (LTL) is short, while the plasma level of Von Willebrand (VWF) is high in persons with atherosclerosis. Moreover, both short LTLs and high VWF levels are observed in individuals who display risks for atherosclerosis, including hypertension, obesity, insulin resistance, cigarette smoking and low socio-economic status. We examined the association between LTL and VWF plasma levels to test the hypothesis that high levels of VWF promote an increase in the turnover of blood cells, including leukocytes. Such a process would heighten the rate of age-dependent LTL attrition, ultimately resulting in shortened LTL. Methods We studied 3 cohorts: the ADELAHYDE study (age 60–87 years), the ERA study (age 41–88 years) and the Longitudinal Study of Aging Danish Twins (LSADT) (age 73–94 years). Results Multiple regression analysis with LTL as the dependent variable, and age, sex and VWF as the independent variables showed that LTL was inversely correlated with VWF in the ADELAHYDE (beta = − 0.125, p < 0.001) and the ERA study (beta = − 0.148, p = 0.010). The LSADT displayed VWF x age interaction, which was incorporated into the model, showing that LTL was also inversely correlated with VWF (beta = − 0.057, p = 0.04). Conclusions The inverse relationship between LTL and VWF, observed in 3 different populations, suggests that LTL might be linked to the coagulative status of the individual. Further research will be required to confirm our observations and their clinical ramifications.
ISSN:0049-3848
1879-2472
DOI:10.1016/j.thromres.2010.03.006