P,N-Ligand for Palladium-Catalyzed Ammonia Arylation: Coupling of Deactivated Aryl Chlorides, Chemoselective Arylations, and Room Temperature Reactions

Amazing ammonia: A new air‐stable P,N‐ligand (Mor‐DalPhos) is reported that enables the palladium‐catalyzed cross‐coupling of ammonia to a variety of aryl chloride and aryl tosylate substrates with high chemoselectivity and, for the first time, at room temperature (see scheme; Ad=adamantyl, Ts=para‐...

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Bibliographic Details
Published in:Angewandte Chemie (International ed.) 2010-06, Vol.49 (24), p.4071-4074
Main Authors: Lundgren, Rylan J, Peters, Brendan D, Alsabeh, Pamela G, Stradiotto, Mark
Format: Article
Language:English
Subjects:
ammonia
arylation
homogeneous catalysis
N,P ligands
P ligands
palladium
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Summary:Amazing ammonia: A new air‐stable P,N‐ligand (Mor‐DalPhos) is reported that enables the palladium‐catalyzed cross‐coupling of ammonia to a variety of aryl chloride and aryl tosylate substrates with high chemoselectivity and, for the first time, at room temperature (see scheme; Ad=adamantyl, Ts=para‐toluenesulfonyl).
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201000526