Blockade by Ginseng Extract of the Development of Reverse Tolerance to the Ambulation-Accelerating Effect of Methamphetamine in Mice

Daily repeated administration of methamphetamine (MAP) developed reverse tolerance to its ambulation-accelerating effect. After pretreatment of mice daily with ginseng extract (GE) for 5 days, concomitant injections of MAP and GE suppressed the development of reverse tolerance to the effect of MAP,...

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Bibliographic Details
Published in:Japanese Journal of Pharmacology 1992, Vol.59 (3), p.423-425
Main Authors: Tokuyama, Shogo, Oh, Ki-Wan, Kim, Hack-Seang, Takahashi, Masakatsu, Kaneto, Hiroshi
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Dose-Response Relationship, Drug
Drug Tolerance
Ginseng
Male
Medical sciences
Methamphetamine
Methamphetamine - administration & dosage
Methamphetamine - pharmacology
Mice
Mice, Inbred Strains
Motor Activity - drug effects
Neuropharmacology
Panax
Pharmacology. Drug treatments
Plant Extracts - administration & dosage
Plant Extracts - pharmacology
Plants, Medicinal
Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)
Psychology. Psychoanalysis. Psychiatry
Psychopharmacology
Reverse tolerance
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Summary:Daily repeated administration of methamphetamine (MAP) developed reverse tolerance to its ambulation-accelerating effect. After pretreatment of mice daily with ginseng extract (GE) for 5 days, concomitant injections of MAP and GE suppressed the development of reverse tolerance to the effect of MAP, although GE itself did not affect the spontaneous motor activity of the naive mice. These results provide evidence that GE may be useful for prevention and therapy of the adverse action of MAP.
ISSN:0021-5198
1347-3506
DOI:10.1016/S0021-5198(19)35544-1