Maternal Cytokine Balance on the Third Postpartum Day is Not Affected by the Mode of Delivery after Healthy Pregnancies

Previous reports have suggested that delivery is associated with the induction of inflammatory cytokines. The present study was designed to investigate whether increased cytokine production was present on postpartum day 3 after a normal pregnancy and whether any changes were associated with the mode...

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Bibliographic Details
Published in:Journal of international medical research 2010-01, Vol.38 (1), p.208-213
Main Authors: Gyarmati, B, Bekö, G, Szalay, B, Cseh, Á, Vásárhelyi, B, Treszl, A
Format: Article
Language:English
Subjects:
Adult
Cesarean Section
Cytokines - blood
Delivery, Obstetric
Female
Growth Hormone - blood
Humans
Pilot Projects
Postpartum Period - blood
Pregnancy - blood
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Summary:Previous reports have suggested that delivery is associated with the induction of inflammatory cytokines. The present study was designed to investigate whether increased cytokine production was present on postpartum day 3 after a normal pregnancy and whether any changes were associated with the mode of delivery. In total, 33 pregnant women were enrolled; 18 delivered vaginally and 15 underwent an elective caesarean section (C-section). The levels of 17 cytokines and growth hormones were measured at the beginning of delivery or before anaesthesia and on postpartum day 3. While interleukin (IL)-6 and IL-8 levels decreased significantly postpartum, other cytokine concentrations were comparable before and after delivery. Only IL-7 levels were significantly increased in the C-section patients compared with the vaginal birth patients postpartum. In conclusion, there was no risk of a prolonged maternal inflammatory reaction after an uncomplicated vaginal birth or elective C-section, so it is probably not necessary to consider this as an issue when making a decision on the mode of delivery following uncomplicated pregnancy.
ISSN:0300-0605
1473-2300
DOI:10.1177/147323001003800124