Induction of Tolerance in Renal Transplantation Using Splenic Transplantation: Experimental Study in a Canine Model

Abstract Objective To evaluate in a canine model the induction of tolerance to renal transplantation after splenectomy and splenosis. Materials and Methods This prospective, experimental, comparative, longitudinal study included 4 experimental groups, each comprising 4 dogs. Group 1 (control group)...

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Bibliographic Details
Published in:Transplantation proceedings 2010, Vol.42 (1), p.376-380
Main Authors: Ayala-García, M.A, Soel, J.M, Diaz, E, González, B, Paz, F.J, Cervantes, F, Rodea, E, Muñoz, G, Rodriguez, J.S, Gutiérrez, J, Malacara, J.M
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Body Weight
Creatinine - blood
Dogs
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Graft Rejection - immunology
Graft Rejection - mortality
Hemoglobins - metabolism
Immune Tolerance
Kidney Transplantation - immunology
Kidney Transplantation - mortality
Leukocyte Count
Male
Medical sciences
Models, Animal
Prospective Studies
Spleen - transplantation
Splenectomy
Splenosis - immunology
Surgery
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgery of the urinary system
Survival Analysis
Tissue, organ and graft immunology
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Summary:Abstract Objective To evaluate in a canine model the induction of tolerance to renal transplantation after splenectomy and splenosis. Materials and Methods This prospective, experimental, comparative, longitudinal study included 4 experimental groups, each comprising 4 dogs. Group 1 (control group) underwent renal transplantation only; group 2 underwent renal transplantation and splenectomy; group 3 underwent renal transplantation and splenosis; and group 4 underwent renal transplantation, splenectomy, and splenosis. Survival and degree of rejection were compared between the 4 groups. Results Splenosis improved renal function after transplantation, as indicated by increased serum creatinine concentration (group 3, 6.2 mg/dL vs group 1, 12.9 mg/dL). Comparison of weighted survival curves (corrected for degree of rejection) demonstrated a significant difference between group 2 (66.0 days) and group 4 (66.2 days) vs group 1 (52.7 days) and group 3 (41.2 days) ( P = .05, Wilcoxon rank sum test). Conclusion These results suggest that in this experimental model of renal transplantation, splenosis and splenectomy induce clinical tolerance, as indicated by improved renal function and prolonged recipient survival.
ISSN:0041-1345
1873-2623
DOI:10.1016/j.transproceed.2009.11.009