Evaluation of Brazilian plants on cancer chemoprevention targets in vitro

Cancer is a leading cause of death worldwide. Cancer chemoprevention is one of the promising strategies to decrease its incidence and both plant extracts and natural products may constitute sources of new chemoprevention agents. Some Brazilian species popularly used to treat inflammatory conditions...

Full description

Saved in:
Bibliographic Details
Published in:Phytotherapy research 2010-06, Vol.24 (6), p.928-933
Main Authors: Endringer, Denise C, Valadares, Ydia M, Campana, Priscilla R.V, Campos, Jussara J, Guimarães, Keller G, Pezzuto, John M, Braga, Fernão C
Format: Article
Language:English
Subjects:
Antineoplastic Agents, Phytogenic - pharmacology
Biological and medical sciences
Brazil
cancer chemoprevention
Cyclooxygenase Inhibitors - pharmacology
dihydroisocoumarin
Drug Screening Assays, Antitumor
General pharmacology
Hancornia speciosa
Hep G2 Cells
Humans
inhibition of NF-κB
Jacaranda caroba
Magnoliopsida - chemistry
Medical sciences
NF-kappa B - metabolism
Ornithine Decarboxylase - metabolism
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Plant Extracts - pharmacology
Solanum paniculatum
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Cancer is a leading cause of death worldwide. Cancer chemoprevention is one of the promising strategies to decrease its incidence and both plant extracts and natural products may constitute sources of new chemoprevention agents. Some Brazilian species popularly used to treat inflammatory conditions were selected for evaluation for cancer chemoprevention. A total of 32 extracts/fractions from Hancornia speciosa, Davilla elliptica, Jacaranda caroba, Mansoa hirsuta, Remija ferrugina, Solanum paniculatum and Xyris pterygoblephara, along with a mixture of ursolic and oleanolic acids obtained from J. caroba and a dihydroisocoumarin isolated from aerial parts of X. pterygoblephara were tested for their cancer chemoprevention activity [inhibition of 12-O-tetradecanoyl-13-acetate (TPA)-mediated NF-κB activation, ornithine decarboxylase (ODC) and cyclooxygenase-1 (COX-1); induction of antioxidant response element (ARE)]. Several extracts / fractions were active in more than one assay and those from H. speciosa, M. hirsuta and J. caroba mediated strong responses with NF-κB, COX-1 and ARE, respectively. Copyright © 2009 John Wiley & Sons, Ltd.
ISSN:0951-418X
1099-1573
DOI:10.1002/ptr.3050