A nitroenolate approach to the synthesis of 4,5-disubstituted-2-aminoimidazoles. Pilot library assembly and screening for antibiotic and antibiofilm activity

A library of 4,5-disubstituted-2-aminoimidazoles was synthesized using a nitroenolate route and then screened for antibiofilm and antimicrobial activity. These compounds displayed notable biofilm dispersal and planktonic microbicidal activity against various Gram-positive and Gram-negative bacteria.

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Published in:Organic & biomolecular chemistry 2010-06, Vol.8 (12), p.2814-2822
Main Authors: Su, Zhaoming, Rogers, Steven A, McCall, W Steve, Smith, Alicia C, Ravishankar, Sindhu, Mullikin, Trey, Melander, Christian
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - chemical synthesis
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
Biofilms
Gram-Negative Bacteria - drug effects
Gram-Negative Bacteria - physiology
Imidazoles - chemistry
Microbial Sensitivity Tests
Structure-Activity Relationship
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cited_by cdi_FETCH-LOGICAL-c316t-d72f9730e86722e77965577f5744f8e63a8ae05f88b15c9b603d7b55b7b4c1fa3
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container_end_page 2822
container_issue 12
container_start_page 2814
container_title Organic & biomolecular chemistry
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creator Su, Zhaoming
Rogers, Steven A
McCall, W Steve
Smith, Alicia C
Ravishankar, Sindhu
Mullikin, Trey
Melander, Christian
description A library of 4,5-disubstituted-2-aminoimidazoles was synthesized using a nitroenolate route and then screened for antibiofilm and antimicrobial activity. These compounds displayed notable biofilm dispersal and planktonic microbicidal activity against various Gram-positive and Gram-negative bacteria.
doi_str_mv 10.1039/c001479f
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source Royal Society of Chemistry
subjects Anti-Bacterial Agents - chemical synthesis
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
Biofilms
Gram-Negative Bacteria - drug effects
Gram-Negative Bacteria - physiology
Imidazoles - chemistry
Microbial Sensitivity Tests
Structure-Activity Relationship
title A nitroenolate approach to the synthesis of 4,5-disubstituted-2-aminoimidazoles. Pilot library assembly and screening for antibiotic and antibiofilm activity
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