Alstiphyllanines A−D, Indole Alkaloids from Alstonia macrophylla

Four new alkaloids, alstiphyllanines A−D (1−4), were isolated from Alstonia macrophylla, and their structures were determined by MS and 2D NMR analyses. Alkaloids 1−4 showed moderate antiplasmodial activity against Plasmodium falciparum and vasorelaxant activity against phenylephrine-induced contrac...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2009-02, Vol.72 (2), p.304-307
Main Authors: Hirasawa, Yusuke, Arai, Hiroko, Zaima, Kazumasa, Oktarina, Rice, Rahman, Abdul, Ekasari, Wiwied, Widyawaruyanti, Aty, Indrayanto, Gunawan, Zaini, Noor Cholies, Morita, Hiroshi
Format: Article
Language:English
Subjects:
alstiphyllanine
Alstonia - chemistry
Alstonia macrophylla
Animals
Antimalarials - chemistry
Antimalarials - isolation & purification
Antimalarials - pharmacology
antiprotozoal activity
aorta
Aorta - drug effects
Biological and medical sciences
chemical structure
Endothelium - drug effects
General pharmacology
human diseases
indole alkaloids
Indole Alkaloids - chemistry
Indole Alkaloids - isolation & purification
Indole Alkaloids - pharmacology
Indonesia
malaria
Medical sciences
Molecular Structure
monoterpenoids
Muscle Contraction - drug effects
Nuclear Magnetic Resonance, Biomolecular
Parasitic Sensitivity Tests
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Phenylephrine - pharmacology
Plasmodium falciparum
Plasmodium falciparum - drug effects
Rats
smooth muscle
spectral analysis
stereochemistry
vasodilation
Vasodilator Agents - pharmacology
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Summary:Four new alkaloids, alstiphyllanines A−D (1−4), were isolated from Alstonia macrophylla, and their structures were determined by MS and 2D NMR analyses. Alkaloids 1−4 showed moderate antiplasmodial activity against Plasmodium falciparum and vasorelaxant activity against phenylephrine-induced contraction of isolated rat aorta.
ISSN:0163-3864
1520-6025
DOI:10.1021/np8007107