Inhibitory effect of quercetin on periodontal pathogens in vitro

Actinobacillus actinomycetemcomitans (Aa) and Porphyromonas gingivalis (Pg) are bacteria strongly associated with early onset, progressive and refractory periodontal disease and associated alveolar bone loss. Quercetin is a flavonoid found in many foods including apples, onions and tea. The aim of t...

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Published in:Phytotherapy research 2010-06, Vol.24 (6), p.817-820
Main Authors: Geoghegan, F., Wong, R.W.K., Rabie, A.B.M.
Format: Article
Language:English
Subjects:
Actinobacillus actinomycetemcomitans (Aa)
Aggregatibacter actinomycetemcomitans - drug effects
Aggregatibacter actinomycetemcomitans - growth & development
Biological and medical sciences
Candida - drug effects
Candida - growth & development
Colony Count, Microbial
General pharmacology
Medical sciences
Microbial Sensitivity Tests
Periodontal Diseases - microbiology
periodontal pathogens
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Porphyromonas gingivalis (Pg)
Porphyromonas gingivalis - drug effects
Porphyromonas gingivalis - growth & development
Quercetin - pharmacology
quertin
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Summary:Actinobacillus actinomycetemcomitans (Aa) and Porphyromonas gingivalis (Pg) are bacteria strongly associated with early onset, progressive and refractory periodontal disease and associated alveolar bone loss. Quercetin is a flavonoid found in many foods including apples, onions and tea. The aim of this study was to evaluate the effect of quercetin on in vitro growth of periodontal pathogens Aa and Pg. For comparison, quercetin's effect on several oral microbes was also evaluated. Different concentrations of quercetin solution were added to calibrated suspensions of Aa and Pg. All suspensions were incubated for 1, 3, 6, and 24 h in an anaerobic chamber at 37°C. At each time point, selected dilutions from each culture broth were plated on blood agar plates. Colonies appearing on blood agar plates were visually counted on 3 days for Aa and 5 days for Pg. Minimum inhibitory concentrations of both periodontal pathogens were also determined. Both periodontal bacteria showed a significant decrease (p < 0.05) in viable counts after 1 h. No colony forming units of Pg could be observed after 24 h. The results suggest that quercetin possesses significant antimicrobial properties on periodontal pathogens in vitro. Copyright © 2009 John Wiley & Sons, Ltd.
ISSN:0951-418X
1099-1573
DOI:10.1002/ptr.3014