Virus-Specific CD8 T Cells in Peripheral Tissues Are More Resistant to Apoptosis Than Those in Lymphoid Organs

CD8 T cells persist at high frequencies in peripheral organs after resolution of an immune response, and their presence in the periphery is important for resistance to secondary challenge. We show here that LCMV-specific T cells in peripheral tissue (peritoneal cavity, lung, fat pads) reacted much l...

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Bibliographic Details
Published in:Immunity (Cambridge, Mass.) Mass.), 2003-05, Vol.18 (5), p.631-642
Main Authors: Wang, Xiaoting Z, Stepp, Susan E, Brehm, Michael A, Chen, Hong D, Selin, Liisa K, Welsh, Raymond M
Format: Article
Language:English
Subjects:
Animals
Annexin A5 - metabolism
Apoptosis
Apoptosis - immunology
Arenaviridae Infections - immunology
Arenaviridae Infections - pathology
CD8-Positive T-Lymphocytes - immunology
Cell cycle
Cell division
Cell Survival - immunology
Immunologic Memory
Infections
Ligands
Lymphocytes
Lymphocytic choriomeningitis virus
Lymphoid Tissue - immunology
Mice
Organ Specificity - immunology
Spleen
T cell receptors
Viral infections
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Summary:CD8 T cells persist at high frequencies in peripheral organs after resolution of an immune response, and their presence in the periphery is important for resistance to secondary challenge. We show here that LCMV-specific T cells in peripheral tissue (peritoneal cavity, lung, fat pads) reacted much less with the apoptotic marker Annexin-V than those in spleen and lymph nodes. This was not due to a TCR-based selection. In comparison to lymphoid tissue, T cells in the periphery expressed lower levels of Fas and Fas ligand and were resistant to activation-induced cell death in vitro. This may contribute to the survival of nondividing peripheral memory T cells, enabling them to efficiently function without being driven into apoptosis.
ISSN:1074-7613
1097-4180
DOI:10.1016/S1074-7613(03)00116-X