Euphane and Tirucallane Triterpenes from the Roots of Euphorbia kansui and Their in Vitro Effects on the Cell Division of Xenopus

Four new euphane-type triterpenes, kansenone (1), kansenonol (3), 11-oxo-kansenonol (4), kansenol (5), and a new tirucallane-type triterpene, epi-kansenone (2), were isolated from a 60% EtOH extract of Euphorbia kansui, together with α-euphol. Their structures were elucidated on the basis of extensi...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2003-05, Vol.66 (5), p.630-633
Main Authors: Wang, Li-Yan, Wang, Nai-Li, Yao, Xin-Sheng, Miyata, Syohei, Kitanaka, Susumu
Format: Article
Language:English
Subjects:
11-oxo-kansenonol
Animals
Antineoplastic Agents, Phytogenic - chemistry
Antineoplastic Agents, Phytogenic - isolation & purification
Antineoplastic Agents, Phytogenic - pharmacology
Biological and medical sciences
carbon
cell division
Cell Division - drug effects
chemical structure
Drugs, Chinese Herbal - chemistry
epi-kansenone
euphane triterpene
Euphorbia
Euphorbia - chemistry
Euphorbiaceae
Eurhorbia kansui
General pharmacology
kan sui
kansenol
kansenone
kansenonol
ketones
Medical sciences
methine
methylene
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
phytochemicals
plant extracts
Plant Roots - chemistry
Plants, Medicinal - chemistry
protons
roots
spectral analysis
stereochemistry
tirucallane triterpene
Triterpenes - chemistry
Triterpenes - isolation & purification
Triterpenes - pharmacology
triterpenoids
Xenopus - embryology
Xenopus laevis
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Summary:Four new euphane-type triterpenes, kansenone (1), kansenonol (3), 11-oxo-kansenonol (4), kansenol (5), and a new tirucallane-type triterpene, epi-kansenone (2), were isolated from a 60% EtOH extract of Euphorbia kansui, together with α-euphol. Their structures were elucidated on the basis of extensive analysis of their 1D and 2D NMR spectral data. This appears to be the first report of the natural occurrence of euphane/tirucallane-type triterpenes with a ketone at C-7. In vitro treatment of cultured individual Xenopus laevis cells at the blastular stage with 1−4 significantly arrested cleavage of the cells (10 μg/mL of each compound resulted in >50% cleavage arrest).
ISSN:0163-3864
1520-6025
DOI:10.1021/np0205396