Protective Value of a Folkloric Medicinal Plant Extract Against Mortality and Hemorrhage in a Life-threatening Renal Trauma Model

• Published in: Urology (Ridgewood, N.J.) N.J.), 2010-06, Vol.75 (6), p.1515.e9-1515.e14
• Main Authors: Tokgöz, Hüsnü, Karakaya, Kemal, Hancı, Volkan, Abduşoğlu, Mustafa, Erol, Bülent, Türksoy, Özlem, Akduman, Bülent, Mungan, Necmettin Aydın
• Format: Article
• Language: English
• Subjects: Animals; Cellulose, Oxidized - pharmacology; Cellulose, Oxidized - therapeutic use; Disease Models, Animal; Hemorrhage - drug therapy; Hemorrhage - prevention & control; Hemostatics - therapeutic use; Injury Severity Score; Kidney - drug effects; Kidney - injuries; Male; Nephrectomy - methods; Phytotherapy - methods; Plant Extracts - therapeutic use; Probability; Random Allocation; Rats; Rats, Wistar; Risk Assessment; Statistics, Nonparametric; Survival Rate; Treatment Outcome; Urology; Wounds and Injuries - drug therapy; Wounds and Injuries - mortality
• ISSN: 0090-4295; 1527-9995
• DOI: 10.1016/j.urology.2009.12.016

Objectives To compare the efficacy of a folkloric medicinal plant extract (Ankaferd Blood Stopper [ABS]) with that of oxidized cellulose (Surgicel) in a life-threatening renal injury model. ABS is a mixture of 5 plants that has historically been used in Turkish traditional medicine. It has been approved by the Ministry of Health to manage external hemorrhage and dental surgery bleeding in Turkey. Methods Twenty-two Wistar albino rats underwent partial nephrectomy after intravenous heparin anticoagulation (2000 U/kg). The cut surface received 1 of 3 therapies, namely no treatment, Surgicel (Johnson & Johnson, New Brunswick, NJ) or ABS (Trend Teknoloji İaç AŞ, Istanbul, Turkey). Blood pressure was continually monitored. Survival time, total blood loss, and mean arterial pressure were recorded for 60 minute or until death. Rats that were alive (mean arterial pressure ≥20 mm Hg) at the end of 60 minutes were sacrificed with blood withdrawal with the help of catheters. Results All animals that received no treatment died within 60 minutes of follow-up. One of 7 in the Surgicel group, and 5 of 7 animals in the ABS group, survived. Mean survival times for the Surgicel and ABS groups were 42.7 and 53.4 minutes, respectively. Rats in the ABS and Surgicel groups survived significantly longer than rats in the control group ( P