GH-releasing Peptide-2 does not Stimulate Arginine Vasopressin Secretion in Healthy Men

Ghrelin has a stimulating effect on arginine vasopressin (AVP). However, it is not known whether GHRP-2, a synthetic ghrelin receptor agonist, also has a stimulating effect on AVP release in men. To determine whether the GHRP-2 test is useful for assessing AVP secretion, blood ACTH, GH, FSH, LH, PRL...

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Bibliographic Details
Published in:Endocrine Journal 2010, Vol.57(2), pp.175-180
Main Authors: KAMOI, Kyuzi, MINAGAWA, Shinichi, KIMURA, Keita, ISHIZAWA, Masahiro, OHARA, Nobumasa, UEMURA, Yasuyuki, TSUCHIYA, Junpei
Format: Article
Language:English
Subjects:
ACTH
Adrenocorticotropic Hormone - metabolism
Adult
Arginine Vasopressin - metabolism
AVP
Fasting
GHRP-2 test
Human Growth Hormone - metabolism
Humans
Male
Oligopeptides
Osmolar Concentration
PRL
Urine - chemistry
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Summary:Ghrelin has a stimulating effect on arginine vasopressin (AVP). However, it is not known whether GHRP-2, a synthetic ghrelin receptor agonist, also has a stimulating effect on AVP release in men. To determine whether the GHRP-2 test is useful for assessing AVP secretion, blood ACTH, GH, FSH, LH, PRL, TSH and AVP levels, as well as glucose, osmolality, sodium and hematocrit, were measured before and 15, 30, 45 and 60 min after an intravenous bolus of 100 μg GHRP-2 in 10 healthy men with and without fasting. Blood pressure was measured at 15-min intervals. AVP secretion was not stimulated by the GHRP-2 test with and without fasting. There were no significant differences in hematocrit, blood pressure and plasma osmolality before and after GFRP-2 injection, although significant (p
ISSN:0918-8959
1348-4540
DOI:10.1507/endocrj.K09E-215