CLINICAL STUDIES ON IMIPENEM/CILASTATIN SODIUM IN THE FIELD OF OBSTETRICS AND GYNECOLOGY

The efficacy and safety of imipenem/cilastatin sodium (IPM/CS) were studied in patients with obstetric and gynecologic infections and in those given the drug as prophylaxis against postoperative infections.The following results were obtained: 1.Efficacy rates were 96.0% (48/50) in patients with obst...

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Bibliographic Details
Published in:Japanese journal of antibiotics 1992/08/25, Vol.45(8), pp.1029-1038
Main Authors: CHIMURA, TETSURO, BANZAI, MICHIO, NARA, NORIHIRO, KAWACHIYA, SATOSHI, OGAWA, TETSUJI, MIYATA, REISUKE, YAMAZAKI, KUNIO, AOYAMA, SHINGO, MATSUO, MASAKI, YOKOYAMA, YUKIO, OHNUMA, YASUHIKO, KANASUGI, HIROSHI, TAKAHASHI, HIDEYUKI, ODA, TAKAHARE, HASEGAWA, TAKESHI, KIHARA, KAORI, KAN, SHIGEZOH, SANJOH, NORIO, MORISAKI, NOBUYUKI, MORISAKI, JUNKO
Format: Article
Language:Japanese
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Bacterial Infections - drug therapy
Bacterial Infections - prevention & control
Cilastatin - therapeutic use
Drug Therapy, Combination - administration & dosage
Drug Therapy, Combination - therapeutic use
Female
Genital Diseases, Female - drug therapy
Humans
Imipenem - administration & dosage
Imipenem - therapeutic use
Infusions, Intravenous
Middle Aged
Postoperative Complications - prevention & control
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Summary:The efficacy and safety of imipenem/cilastatin sodium (IPM/CS) were studied in patients with obstetric and gynecologic infections and in those given the drug as prophylaxis against postoperative infections.The following results were obtained: 1.Efficacy rates were 96.0% (48/50) in patients with obstetric and gynecologic infections and 100% (28/28) in those with urinary tract or other infections.The overall efficacy rate was 97.4% (76/78).Bacteriologically, 30 organisms were isolated from 28 patients.The eradication rate was 95.2% (20/21) and the efficacy rate was 96.4% (27/28). 2.Changes in blood elastase before and after treatment were compared with those in CRP, WBC, and ESR in the patients with obstetric and gynecologic infections.The changes in elastase were similar to those in CRP. 3.The efficacy rate was 98.0% (48/49) in the patients given prophylaxis against postoperative obstetric and gynecologic infections. 4.An adverse reaction was observed in only one patient (diarrhea), and abnormal laboratory findings were noted in 2 patients (elevation of GOT and GPT). These results indicate that IPM/CS is very useful for the treatment of obstetric and gynecologic infections.
ISSN:0368-2781
2186-5477
DOI:10.11553/antibiotics1968b.45.1029