Thrombocytopenia in Patients With Chronic Hepatitis C: A Possible Role of HCV on Platelet Progenitor Cell Maturation

A total of 30 patients with chronic hepatitis C (HCV) thrombocytopenia (TP) and 20 healthy controls were studied. Both groups were subjected to complete medical history, clinical examination in addition to assessment of hepatitis markers: level of thrombopoietin (Tpo), Geimsa-stained bone marrow sme...

Full description

Saved in:
Bibliographic Details
Published in:Angiology 2010-04, Vol.61 (3), p.304-313
Main Authors: El Barbary, Magdy A., Saad, Alaa Eldin M., Attia, Fadia M., Mandour, Magda I., Haidara, Mohamed A., Dallak, Mohammad M., Isenovic, Esma R.
Format: Article
Language:English
Subjects:
Blood Platelets - physiology
Colony-Forming Units Assay
Hepacivirus - physiology
Hepatitis C, Chronic - blood
Hepatitis C, Chronic - complications
Humans
Megakaryocytes - physiology
Platelet Count
Prothrombin Time
Stem Cells - physiology
Thrombocytopenia - blood
Thrombocytopenia - complications
Thrombocytopenia - virology
Thrombopoietin - blood
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A total of 30 patients with chronic hepatitis C (HCV) thrombocytopenia (TP) and 20 healthy controls were studied. Both groups were subjected to complete medical history, clinical examination in addition to assessment of hepatitis markers: level of thrombopoietin (Tpo), Geimsa-stained bone marrow smears, and in vitro short-term megakaryocytic progenitors culture (CFU-MK). Serum Tpo level was significantly elevated in patients with TP HCV. Short-term CFU-MK showed an evident depression in the colony-forming unit—megakaryocyte (CFU-meg). There is a positive correlation between the number of CFU-meg and the platelet count and between serum Tpo level and prothrombin time, transaminase, albumin, and the Child Pugh score of liver disease; a negative correlation between serum Tpo level and the number of CFU-meg and between serum Tpo level and the platelet count. Thus, the level of Tpo could be an indicator of intact functional response of the hepatocytes.
ISSN:0003-3197
1940-1574
DOI:10.1177/0003319709343178