Lack of Protective Immunity Against Reinfection with Hepatitis C Virus

Some individuals infected with hepatitis C virus (HCV) experience multiple episodes of acute hepatitis. It is unclear whether these episodes are due to reinfection with HCV or to reactivation of the original virus infection. Markers of viral replication and host immunity were studied in five chimpan...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1992-10, Vol.258 (5079), p.135-140
Main Authors: Farci, Patrizia, Alter, Harvey J., Govindarajan, Sugantha, Wong, Doris C., Engle, Ronald, Lesniewski, Richard R., Mushahwar, Isa K., Desai, Suresh M., Miller, Roger H., Ogata, Norio, Purcell, Robert H.
Format: Article
Language:English
Subjects:
Acute Disease
Aged
Alanine Transaminase - biosynthesis
Animals
Antibodies
Base Sequence
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
Hepacivirus - physiology
Hepatitis
Hepatitis Antibodies - biosynthesis
Hepatitis C
Hepatitis C - immunology
Hepatitis C Antibodies
hepatitis C virus
Humans
Immunity
Immunity (Physiology)
Immunity, Active
Infections
Inoculation
Liver
Longitudinal Studies
Microbiology
Molecular Sequence Data
Pan troglodytes
Physiological aspects
Polymerase Chain Reaction
Reinfection
RNA
Sequence Homology
Transcription, Genetic
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies
Viremia
Virology
Virus Replication
Viruses
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Description
Summary:Some individuals infected with hepatitis C virus (HCV) experience multiple episodes of acute hepatitis. It is unclear whether these episodes are due to reinfection with HCV or to reactivation of the original virus infection. Markers of viral replication and host immunity were studied in five chimpanzees sequentially inoculated over a period of 3 years with different HCV strains of proven infectivity. Each rechallenge of a convalescent chimpanzee with the same or a different HCV strain resulted in the reappearance of viremia, which was due to infection with the subsequent challenge virus. The evidence indicates that HCV infection does not elicit protective immunity against reinfection with homologous or heterologous strains, which raises concerns for the development of effective vaccines against HCV.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.1279801