Fetal cerebral periventricular halo at midgestation: an ultrasound finding suggestive of fetal cytomegalovirus infection

Objective The objective of the study was to identify a cerebral ultrasound finding indicative of fetal cytomegalovirus (CMV) infection at midgestation. Study Design All fetuses of 218 patients with primary CMV infection underwent prospective transvaginal neurosonographic examination at 20-22 weeks&#...

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Bibliographic Details
Published in:American journal of obstetrics and gynecology 2010-06, Vol.202 (6), p.599.e1-599.e5
Main Authors: Simonazzi, Giuliana, MD, Guerra, Brunella, MD, Bonasoni, Paola, MD, Pilu, Gianluigi, MD, Lazzarotto, Tiziana, MD, Santini, Donatella, MD, Rizzo, Nicola, MD
Format: Article
Language:English
Subjects:
Biological and medical sciences
Brain - pathology
congenital cytomegalovirus
Cytomegalovirus Infections - diagnostic imaging
Cytomegalovirus Infections - pathology
Female
fetal brain
Fetal Diseases - diagnostic imaging
Fetal Diseases - pathology
Gynecology. Andrology. Obstetrics
Humans
Infectious diseases
Medical sciences
Necrosis - pathology
Obstetrics and Gynecology
Pregnancy
Pregnancy Complications, Infectious - diagnostic imaging
Pregnancy Complications, Infectious - pathology
Retrospective Studies
telencephalic leukomalacia
transvaginal ultrasound
Ultrasonography, Prenatal
Viral diseases
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Summary:Objective The objective of the study was to identify a cerebral ultrasound finding indicative of fetal cytomegalovirus (CMV) infection at midgestation. Study Design All fetuses of 218 patients with primary CMV infection underwent prospective transvaginal neurosonographic examination at 20-22 weeks' gestation. Results Transvaginal sonography identified a periventricular echogenic halo with well-defined borders in 6 infected fetuses at a mean gestational age of 20.5 weeks. Transabdominal axial views of the fetal head were normal in all cases. All patients opted for termination of pregnancy. Autopsy in 2 fetuses showed changes compatible with subacute white matter injury resembling telencephalic leukomalacia. Conclusion A fetal cerebral periventricular halo disclosed by transvaginal sonography at midgestation in pregnant patients with recent CMV infection is suggestive of fetal infection and may be associated with white matter lesions.
ISSN:0002-9378
1097-6868
DOI:10.1016/j.ajog.2009.12.021